Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization

doi:10.3390/molecules23030594

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization
	Qin, Yukun 1,2; Liu, Weixiang 1,2,3; Xing, Ronge1,2 ; Liu, Song 1,2; Li, Kecheng 1,2; Li, Pengcheng1,2
刊名	MOLECULES
	2018-03-01
卷号	23 期号:3 页码:13
关键词	synthesis 1,2,4-triazolyl acyl thiourea chitosan antifungal activity
ISSN号	1420-3049
DOI	10.3390/molecules23030594
英文摘要	In this study, 3-methyl-1,2,4-triazolyl chitosan (MTACS) and 3-chloromethyl-1,2,4-triazolyl chitosan (CMTACS) were prepared via cyclization of acyl thiourea chitosan (TUGS). Their structures were confirmed by FT-IR, H-1-NMR, elemental analysis, DSC, XRD, and SEM. The conformations were predicted using the Gaussian 09 program. Additionally, the antifungal properties of MTACS and CMTACS against Stemphylium solani weber (S. solani), Alternaria porn (A. porfi), and Gloeosporium theae-sinensis (G. theae-sinensis) were assayed in vitro and ranged from 250 mu g/mL to 1000 mu g/mL. The results showed that MTACS and CMTACS exhibited enhanced inhibitory effect on the selected fungi compared to the original chitosan and TUCS. In particular, they displayed better antifungal activities against A. porn and G. theae-sinensis than that of the positive control, Triadimefon. The findings described here may lead to them being used as antifungal agents for crop protection.
资助项目	Key Research Program of the Chinese Academy of Sciences[KFZD-SW-106] ; National Natural Science Foundation of China[41306071] ; Qingdao science and technology plan[17-3-3-60-nsh] ; NSFC Shandong joint fund[U1606403]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000428514100085
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/158969]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Qin, Yukun; Li, Pengcheng
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Qin, Yukun,Liu, Weixiang,Xing, Ronge,et al. Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization[J]. MOLECULES,2018,23(3):13.
APA	Qin, Yukun,Liu, Weixiang,Xing, Ronge,Liu, Song,Li, Kecheng,&Li, Pengcheng.(2018).Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization.MOLECULES,23(3),13.
MLA	Qin, Yukun,et al."Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization".MOLECULES 23.3(2018):13.