Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization | |
Qin, Yukun1,2; Liu, Weixiang1,2,3; Xing, Ronge1,2![]() ![]() | |
刊名 | MOLECULES
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2018-03-01 | |
卷号 | 23期号:3页码:13 |
关键词 | synthesis 1,2,4-triazolyl acyl thiourea chitosan antifungal activity |
ISSN号 | 1420-3049 |
DOI | 10.3390/molecules23030594 |
英文摘要 | In this study, 3-methyl-1,2,4-triazolyl chitosan (MTACS) and 3-chloromethyl-1,2,4-triazolyl chitosan (CMTACS) were prepared via cyclization of acyl thiourea chitosan (TUGS). Their structures were confirmed by FT-IR, H-1-NMR, elemental analysis, DSC, XRD, and SEM. The conformations were predicted using the Gaussian 09 program. Additionally, the antifungal properties of MTACS and CMTACS against Stemphylium solani weber (S. solani), Alternaria porn (A. porfi), and Gloeosporium theae-sinensis (G. theae-sinensis) were assayed in vitro and ranged from 250 mu g/mL to 1000 mu g/mL. The results showed that MTACS and CMTACS exhibited enhanced inhibitory effect on the selected fungi compared to the original chitosan and TUCS. In particular, they displayed better antifungal activities against A. porn and G. theae-sinensis than that of the positive control, Triadimefon. The findings described here may lead to them being used as antifungal agents for crop protection. |
资助项目 | Key Research Program of the Chinese Academy of Sciences[KFZD-SW-106] ; National Natural Science Foundation of China[41306071] ; Qingdao science and technology plan[17-3-3-60-nsh] ; NSFC Shandong joint fund[U1606403] |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
出版者 | MDPI |
WOS记录号 | WOS:000428514100085 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://ir.qdio.ac.cn/handle/337002/158969] ![]() |
专题 | 海洋研究所_实验海洋生物学重点实验室 |
通讯作者 | Qin, Yukun; Li, Pengcheng |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Qin, Yukun,Liu, Weixiang,Xing, Ronge,et al. Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization[J]. MOLECULES,2018,23(3):13. |
APA | Qin, Yukun,Liu, Weixiang,Xing, Ronge,Liu, Song,Li, Kecheng,&Li, Pengcheng.(2018).Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization.MOLECULES,23(3),13. |
MLA | Qin, Yukun,et al."Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization".MOLECULES 23.3(2018):13. |
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