Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection | |
Li, Mo-Fei1,2![]() | |
刊名 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
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2018-02-01 | |
卷号 | 79页码:142-149 |
关键词 | Complement regulatory protein Complement activation Cynoglossus semilaevis Bacterial infection |
ISSN号 | 0145-305X |
DOI | 10.1016/j.dci.2017.10.008 |
通讯作者 | Sun, Li(lsun@qdio.ac.cn) |
英文摘要 | In mammals, membrane-associated complement regulatory proteins (MCRP) can protect host cells from the damaging of the activated complement. In teleost, few studies on the function of MCRP have been documented. In the present report, we identified a MCRP (named CsMCRP) from the teleost fish tongue sole Cynoglossus semilaevis and examined its immune function. CsMCRP shares moderate sequence identities with fish DAF-like molecules. CsMCRP was predicted to be a transmembrane protein with three short consensus repeats located in the extracellular region. CsMCRP expression occurred in nine different tissues, especially blood, and in peripheral blood leukocytes (PBL). Recombinant CsMCRP inhibited complement activation and interacted with bacterial pathogen, the latter in a highly selective manner. Antibody blocking the CsMCRP on PBL significantly inhibited bacterial infection of PBL. These results indicate that teleost CsMCRP is both a regulator of complement activation and a cellular receptor involved in bacterial invasion. (C) 2017 Elsevier Ltd. All rights reserved. |
资助项目 | National Natural Science Foundation of China[31330081] ; AoShan Talents Program ; Qingdao National Laboratory for Marine Science and Technology[2015ASTP] ; Taishan Scholar Program of Shandong Province |
WOS研究方向 | Fisheries ; Immunology ; Zoology |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000422811500016 |
内容类型 | 期刊论文 |
源URL | [http://ir.qdio.ac.cn/handle/337002/157816] ![]() |
专题 | 海洋研究所_实验海洋生物学重点实验室 |
通讯作者 | Sun, Li |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Mo-Fei,Sun, Li. Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2018,79:142-149. |
APA | Li, Mo-Fei,&Sun, Li.(2018).Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,79,142-149. |
MLA | Li, Mo-Fei,et al."Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 79(2018):142-149. |
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