Resting-state Functional Magnetic Resonance Imaging Analysis of Brain Functional Activity in Rats with Ischemic Stroke Treated by Electro-acupuncture

doi:10.1016/j.jstrokecerebrovasdis.2017.06.018

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	Resting-state Functional Magnetic Resonance Imaging Analysis of Brain Functional Activity in Rats with Ischemic Stroke Treated by Electro-acupuncture
	Liang, SX; Lin, YJ; Lin, BB; Li, JH; Liu, WL; Chen, LD; Zhao, SJ; Tao, J; Liang SX(梁胜祥)
刊名	JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
	2017
卷号	26 期号:9 页码:1953-1959
关键词	Electro-acupuncture ischemic stroke functional magnetic resonance imaging regional homogeneity
ISSN号	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2017.06.018
文献子类	Article
英文摘要	Objective: To evaluate whether electro-acupuncture (EA) treatment at acupoints of Zusanli (ST 36) and Quchi (LI 11) could reduce motor impairments and enhance brain functional recovery in rats with ischemic stroke. Materials and Methods: A rat model of middle cerebral artery occlusion (MCAO) was established. EA at ST 36 and LI 11was started at 24 hours (MCAO + EA group) after ischemic stroke. The nontreatment (MCAO) and sham-operated control (SC) groups were included as controls. The neurologic deficits of all groups were assessed by Zea Longa scores and the modified neurologic severity scores on 24 hours and 8 days after MCAO. To further investigate the effect of EA on infract volume and brain function, magnetic resonance imaging was used to estimate the brain lesion and brain neural activities of each group at 8 days after ischemic stroke. Results: Within 1 week after EA treatment, the neurologic deficits were significantly alleviated, and the cerebral infarctions were improved, including visual cortex, motor cortex, striatum, dorsal thalamus, and hippocampus. Furthermore, whole brain neural activities of auditory cortex, lateral nucleus group of dorsal thalamus, hippocampus, motor cortex, orbital cortex, sensory cortex, and striatum were decreased in MCAO group, whereas that of brain neural activities were increased after EA treatment, suggesting these brain regions are in accordance with the brain structure analysis. Conclusion: EA at ST 36 and LI 11 could enhance the neural activity of motor functionrelated brain regions, including motor cortex, dorsal thalamus, and striatum in rats, which is a potential treatment for ischemia stroke.
电子版国际标准刊号	1532-8511
WOS关键词	RANDOMIZED CONTROLLED-TRIAL ; CEREBRAL-ARTERY OCCLUSION ; REGIONAL HOMOGENEITY ; SIGNALING PATHWAY ; ACUPUNCTURE ; FMRI ; DISEASE ; PROLIFERATION ; ACTIVATION ; RECOVERY
WOS研究方向	Neurosciences & Neurology ; Cardiovascular System & Cardiology
语种	英语
WOS记录号	WOS:000407805400018
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285253]
专题	高能物理研究所_核技术应用研究中心中国科学院高能物理研究所_中国散裂中子源
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Liang, SX,Lin, YJ,Lin, BB,et al. Resting-state Functional Magnetic Resonance Imaging Analysis of Brain Functional Activity in Rats with Ischemic Stroke Treated by Electro-acupuncture[J]. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,2017,26(9):1953-1959.
APA	Liang, SX.,Lin, YJ.,Lin, BB.,Li, JH.,Liu, WL.,...&梁胜祥.(2017).Resting-state Functional Magnetic Resonance Imaging Analysis of Brain Functional Activity in Rats with Ischemic Stroke Treated by Electro-acupuncture.JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,26(9),1953-1959.
MLA	Liang, SX,et al."Resting-state Functional Magnetic Resonance Imaging Analysis of Brain Functional Activity in Rats with Ischemic Stroke Treated by Electro-acupuncture".JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 26.9(2017):1953-1959.