AuGd integrated nanoprobes for optical/MRI/CT triple-modal in vivo tumor imaging

doi:10.1039/c7nr01064h

	AuGd integrated nanoprobes for optical/MRI/CT triple-modal in vivo tumor imaging
	Zhang CY(张春雨); Xu, C; Wang, YL; Zhang, CY; Jia, YW; Luo, YJ; Gao, XY; Xu C(徐超); Wang YL(王亚玲); Gao XY(高学云)
刊名	NANOSCALE
	2017
卷号	9 期号:13 页码:4620-4628
ISSN号	2040-3364
DOI	10.1039/c7nr01064h
文献子类	Article
英文摘要	Multi-modal imaging agents are desirable for tumor diagnosis because they can provide more information on the tumor than single-modal imaging agents. However, most reported multi-modal imaging agents are dual-modal agents rather than tri-modal agents; therefore, detailed information on the tumor may still be insufficient when such imaging agents are used. To ameliorate this issue, we synthesized a tri-modal imaging agent, composed of gold cluster and gadolinium oxide integrated nanoparticles (denoted as AuGds) using bovine serum albumin (BSA) as the template via a bio-mineralization method. The AuGds exhibit red fluorescence at similar to 660 nm for optical imaging, strong X-ray absorption (around 700 HU) for CT imaging, and a high r(1) value (similar to 12.39 mM(-1) s(-1)) for MR imaging. After being chemically modified with folic acid (FA), the AuGds can specifically target folate receptors on KB tumor cells, and permit in vivo optical, MR, and CT imaging of xenografted tumors. By comparing these three imaging modalities, very clear structural and anatomical information on the in vivo tumor can be obtained. The AuGds show good biocompatibility, quick renal clearance, and do not induce normal tissue toxicity in vivo.
电子版国际标准刊号	2040-3372
WOS关键词	TOMOGRAPHY CONTRAST AGENTS ; COMPUTED-TOMOGRAPHY ; GOLD NANOPARTICLES ; GD2O3 NANOPARTICLES ; CANCER ; FLUORESCENCE ; PROTEIN ; VALIDATION ; T-1
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000397968400029
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285110]
专题	高能物理研究所_加速器中心高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Zhang CY,Xu, C,Wang, YL,et al. AuGd integrated nanoprobes for optical/MRI/CT triple-modal in vivo tumor imaging[J]. NANOSCALE,2017,9(13):4620-4628.
APA	张春雨.,Xu, C.,Wang, YL.,Zhang, CY.,Jia, YW.,...&高学云.(2017).AuGd integrated nanoprobes for optical/MRI/CT triple-modal in vivo tumor imaging.NANOSCALE,9(13),4620-4628.
MLA	张春雨,et al."AuGd integrated nanoprobes for optical/MRI/CT triple-modal in vivo tumor imaging".NANOSCALE 9.13(2017):4620-4628.