Study on orally delivered paclitaxel nanocrystals:modification,characterization and activity in the gastrointestinal tract

doi:10.1098/rsos.170753

	Study on orally delivered paclitaxel nanocrystals:modification,characterization and activity in the gastrointestinal tract
	Xing GM(刑更妹); Li M(李敏); Zhao YL(赵宇亮); Runcong Liu, Ya-Nan Chang, Gengmei Xing, Min Li and Yuliang Zhao; Chang YN(常亚男); Liu RC(刘润聪)
刊名	ROYAL SOCIETY OPEN SCIENCE
	2017
卷号	4 期号:11 页码:170753
关键词	oral delivery paclitaxel nanocrystal gastrointestinal tract
ISSN号	2054-5703
DOI	10.1098/rsos.170753
文献子类	Article
英文摘要	Drug nanocrystals (NCs) can improve the solubility and bioavailability of insoluble drugs for oral administration. However, the biocompatibility and mechanisms of transmittance of drug NCs through the intestinal epithelial tissue are still not well understood. In this work, the physicochemical properties and interactions with biomolecules in oral delivery pathways, as well as the transmittance through mimical intestinal epithelial cells, of NCs of paclitaxel (PTX) are investigated. PTX was previously demonstrated to be an effective anti-cancer drug. It is found that maximum 1% (w/v) poly(styrenesulfonate) is sufficient to keep PTX NCs monodisperse in varied biological environments and presents no significant interaction with extracellular biomolecules for at least 24 h. The concentration of PTX NCs is kept carefully controlled to avoid serious toxicity to cells (10 mu gml(-1) in our experiments but this also depends on NC size). The transmittance of PTX NCs through mimical intestinal epithelial reached 25% in 6 h, demonstrating its comparatively high oral bioavailability in the human body. This work demonstrates the great potential of PTX NC treated in oral delivery.
WOS关键词	POORLY SOLUBLE DRUGS ; CELL LUNG-CANCER ; INSULIN DELIVERY ; IN-VITRO ; NANOPARTICLES ; FORMULATION ; EFFICACY ; CHITOSAN ; COMBINATION ; MONOLAYERS
WOS研究方向	Science & Technology - Other Topics
语种	英语
WOS记录号	WOS:000416787500020
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285101]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Xing GM,Li M,Zhao YL,et al. Study on orally delivered paclitaxel nanocrystals:modification,characterization and activity in the gastrointestinal tract[J]. ROYAL SOCIETY OPEN SCIENCE,2017,4(11):170753.
APA	刑更妹,李敏,赵宇亮,Runcong Liu, Ya-Nan Chang, Gengmei Xing, Min Li and Yuliang Zhao,常亚男,&刘润聪.(2017).Study on orally delivered paclitaxel nanocrystals:modification,characterization and activity in the gastrointestinal tract.ROYAL SOCIETY OPEN SCIENCE,4(11),170753.
MLA	刑更妹,et al."Study on orally delivered paclitaxel nanocrystals:modification,characterization and activity in the gastrointestinal tract".ROYAL SOCIETY OPEN SCIENCE 4.11(2017):170753.