Synthesis of BSA-Coated BiOI@Bi2S3Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor

doi:10.1002/adma.201704136

	Synthesis of BSA-Coated BiOI@Bi2S3Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor
	Zhao, Yuliang; Gu, Zhanjun; Wang, Qing; Xie, Jiani; Dong, Xinghua; Du, Jiangfeng; Zhang, Xiao; Yong, Yuan; Zhu, Shuang; Guo, Zhao
刊名	ADVANCED MATERIALS
	2017
卷号	29 期号:44 页码:1704136
关键词	bismuth oxyiodide photodynamic therapy photothermal therapy radiotherapy semiconductors
ISSN号	0935-9648
DOI	10.1002/adma.201704136
文献子类	Article
英文摘要	Developing an effective theranostic nanoplatform remains a great challenge for cancer diagnosis and treatment. Here, BiOI@Bi2S3@BSA (bovine serum albumin) semiconductor heterojunction nanoparticles (SHNPs) for triple-combination radio/photodynamic/photothermal cancer therapy and multimodal computed tomography/photoacoustic (CT/PA) bioimaging are reported. On the one hand, SHNPs possess strong X-ray attenuation capability since they contain high-Z elements, and thus they are anticipated to be a very competent candidate as radio-sensitizing materials for radiotherapy enhancement. On the other hand, as a semiconductor, the as-prepared SHNPs offer an extra approach for reactive oxygen species generation based on electron-hole pair under the irradiation of X-ray through the photodynamic therapy process. This X-ray excited photodynamic therapy obviously has better penetration depth in bio-tissue. What's more, the SHNPs also possess well photothermal conversion efficiency for photothermal therapy, because Bi2S3 is a thin band semiconductor with strong near-infrared absorption that can cause local overheat. In vivo tumor ablation studies show that synergistic radio/photodynamic/photothermal therapy achieves more significant therapeutic effect than any single treatment. In addition, with the strong X-ray attenuation and high near-infrared absorption, the as-obtained SHNPs can also be applied as a multimodal contrast agent in CT/PA imaging.
电子版国际标准刊号	1521-4095
WOS关键词	PHOTODYNAMIC THERAPY ; GOLD NANOPARTICLES ; RADIATION-THERAPY ; CANCER-TREATMENT ; QUANTUM DOTS ; PHOTOTHERMAL THERAPY ; NECK-CANCER ; RADIOTHERAPY ; RADIOSENSITIZATION ; OXYGEN
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000415905200025
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/284994]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Zhao, Yuliang,Gu, Zhanjun,Wang, Qing,et al. Synthesis of BSA-Coated BiOI@Bi2S3Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor[J]. ADVANCED MATERIALS,2017,29(44):1704136.
APA	Zhao, Yuliang.,Gu, Zhanjun.,Wang, Qing.,Xie, Jiani.,Dong, Xinghua.,...&郭兆.(2017).Synthesis of BSA-Coated BiOI@Bi2S3Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor.ADVANCED MATERIALS,29(44),1704136.
MLA	Zhao, Yuliang,et al."Synthesis of BSA-Coated BiOI@Bi2S3Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor".ADVANCED MATERIALS 29.44(2017):1704136.