Therapeutic Nanoparticles Based on Curcumin and Bamboo Charcoal Nanoparticles for Chemo-Photothermal Synergistic Treatment of Cancer and Radioprotection of Normal Cells

doi:10.1021/acsami.7b02622

	Therapeutic Nanoparticles Based on Curcumin and Bamboo Charcoal Nanoparticles for Chemo-Photothermal Synergistic Treatment of Cancer and Radioprotection of Normal Cells
	Guo Z(郭钊); Xie JN(谢佳妮); Yong Y(雍媛); Dong XH(董兴华); Du JF(杜江锋); Gong LJ(龚林吉); Zhu S(朱爽); Gu ZJ(谷战军); Zhao YL(赵宇亮); Xie, JN
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017
卷号	9 期号:16 页码:14281-14291
关键词	curcumin bamboo charcoal nanoparticles bioavailability chemotherapy photothermal therapy radioprotection
ISSN号	1944-8244
DOI	10.1021/acsami.7b02622
文献子类	Article
英文摘要	Low water solubility, extensive metabblism, and drug resistance are the,exiting unavoidable disadvantages of the insoluble drug curcumin in biomedical applications. Herein, we employed D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS)-functionaliieti near-infrared (NIR)-triggered photothermal mesoporous nanocarriors. with bamboo charcoal nanoparticles (TPGS-BCNPs) to load and deliver curcumni for improving its bioavailability. This system could considerably increase the accumulation of curcumin in cancer cells for enhanced curcumin bioavailability via simultaneously promoting the cellular. internalization of the as-synthesized Composite (TPGS-BCNPs@curcutnin) by the size effect of NPs and: considerably triggering controlled curcurnin release from TPGS-BCNPs@curcumin by NIR stimulation and reducing efflux of curcumin by the P-glycoprotein (P-gp) inhibition of TPGS, so as to enhance the therapeutie effect of curcumin and realize a better chemo-photothermaLsynergetic therapy in vitro and in vivo. Besides cancer therapy, studies indicated that :curcumin and some carbon materials could be used as radical scavengers that play an important role in the radioprotection of normal cells. Hence, we also investigated the free:radical-stavenging ability of the TPGS-BCNPs@curcumin composite in vitro to preliminarily evaluate its radioprotection ability for healthy tissues. Therefore, our work provides a multifunctional delivery system for curcumin bioavailability enhancement, chemo-photothermal synergetic therapy of cancer, and radioprotection of healthy tissues.
WOS关键词	IN-VITRO ; MULTIDRUG-RESISTANCE ; GOLD NANOPARTICLES ; PLGA NANOPARTICLES ; MESOPOROUS SILICA ; CELLULAR UPTAKE ; DRUG-DELIVERY ; APOPTOSIS ; VIVO ; TUMOR
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
WOS记录号	WOS:000400321800053
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/284965]
专题	高能物理研究所_多学科研究中心高能物理研究所_实验物理中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Guo Z,Xie JN,Yong Y,et al. Therapeutic Nanoparticles Based on Curcumin and Bamboo Charcoal Nanoparticles for Chemo-Photothermal Synergistic Treatment of Cancer and Radioprotection of Normal Cells[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(16):14281-14291.
APA	郭钊.,谢佳妮.,雍媛.,董兴华.,杜江锋.,...&Zhao, YL.(2017).Therapeutic Nanoparticles Based on Curcumin and Bamboo Charcoal Nanoparticles for Chemo-Photothermal Synergistic Treatment of Cancer and Radioprotection of Normal Cells.ACS APPLIED MATERIALS & INTERFACES,9(16),14281-14291.
MLA	郭钊,et al."Therapeutic Nanoparticles Based on Curcumin and Bamboo Charcoal Nanoparticles for Chemo-Photothermal Synergistic Treatment of Cancer and Radioprotection of Normal Cells".ACS APPLIED MATERIALS & INTERFACES 9.16(2017):14281-14291.