Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase

doi:10.1002/adhm.201601453

	Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase
	Gao, XY; Yuan, Q; Wang, YL; Liu, R; Cai, PJ; Gao, L; Zheng, WP; Gao, FP; Gao XY(高学云); Zhao YL(赵宇亮)
刊名	ADVANCED HEALTHCARE MATERIALS
	2017
卷号	6 期号:7 页码:1601453
ISSN号	2192-2640
DOI	10.1002/adhm.201601453
文献子类	Article
英文摘要	Photodynamic therapy (PDT) is a minimally invasive therapeutic procedure of tumors with high selectivity and low side effect. However, it is usually not efficient in long-lasting tumor control. One of the main reasons is tumor cells develop some protective mechanisms that help them to deal with oxidative stress in the environment. The thioredoxin system in cancer is an important antioxidant defense system. Au nanoclusters could effectively inhibit thioredoxin reductase (TrxR) in tumor cell cytoplasm. Herein, Au nanoclusters and photosensitizer Chlorine 6 (Ce6) are co-loaded in spatiotemporal controllable liposomal nanocomposites. pH responsive molecule inserted in lipid bilayer greatly contributes to the instability of the lipid membrane in lysosomal at low pH environment. Then the payloads can rapidly release into cytoplasm. Au nanoclusters effectively inhibit TrxR in cytoplasm and enhance the photodynamic-induced intracellular reactive oxygen-free radical concentration, improving the effect of PDT. Breast cancer is chosen as a tumor model and the Au nanoclusters and photosensitizer co-loaded liposomal nanocomposites are studied to improve the effect of PDT both in vitro and in vivo, and its corresponding mechanism is investigated. This study develops a new application of gold nanoclusters and provides a new train of thoughts for enhancing the effect of PDT.
电子版国际标准刊号	2192-2659
WOS关键词	OVARIAN-CANCER ; DRUG-RELEASE ; CELLS ; MECHANISMS ; APOPTOSIS ; SENSITIVITY ; EXPRESSION ; RESISTANCE ; VESICLES ; STRESS
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
语种	英语
WOS记录号	WOS:000399719900012
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/284963]
专题	高能物理研究所_多学科研究中心高能物理研究所_粒子天体物理中心高能物理研究所_管理与技术支持
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Gao, XY,Yuan, Q,Wang, YL,et al. Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase[J]. ADVANCED HEALTHCARE MATERIALS,2017,6(7):1601453.
APA	Gao, XY.,Yuan, Q.,Wang, YL.,Liu, R.,Cai, PJ.,...&Zhao, YL.(2017).Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase.ADVANCED HEALTHCARE MATERIALS,6(7),1601453.
MLA	Gao, XY,et al."Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase".ADVANCED HEALTHCARE MATERIALS 6.7(2017):1601453.