Iron-induced generation of mitochondrial ROS depends on AMPK activity

doi:10.1007/s10534-017-0023-0

	Iron-induced generation of mitochondrial ROS depends on AMPK activity
	Hu Y(胡毅); Huang H(黄辉); Chen J(陈俊); Lu HR(卢会茹); Zhou MX(周梦雪); Chai ZF(柴之芳); Huang, H; Chen, J; Lu, HR; Zhou, MX
刊名	BIOMETALS
	2017
卷号	30 期号:4 页码:623-628
关键词	Fe(II) AMPK Neurotoxicity Mitochondria ROS
ISSN号	0966-0844
DOI	10.1007/s10534-017-0023-0
文献子类	Article
英文摘要	Deregulated iron homeostasis is generally believed to be implicated in neurodegenerative diseases, including Parkinson's disease. Nevertheless, it is not fully understood how iron overload can elicit neuronal cell damage. Here we examined mitochondrial reactive oxygen species (ROS) levels in human dopaminergic neuroblastoma SH-SY5Y cells upon iron exposure. A relatively high concentration of iron could significantly increase mitochondrial ROS levels in SH-SY5Y cells. Pharmacological activation of AMP-activated protein kinase (AMPK) almost completely inhibited the effect of iron on mitochondrial ROS. By contrast, AMPK inhibition aggravated the neurotoxicity of iron and enhanced the production of mitochondrial ROS. Collectively, these findings suggested that excess iron may be able to perturb mitochondrial function, and AMPK activity is important for the association of iron and mitochondria.
电子版国际标准刊号	1572-8773
WOS关键词	PARKINSONS-DISEASE ; SH-SY5Y CELLS ; NEUROTOXICITY ; STRESS ; MTOR ; DRUG
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
WOS记录号	WOS:000405780200014
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/284953]
专题	高能物理研究所_多学科研究中心高能物理研究所_实验物理中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Hu Y,Huang H,Chen J,et al. Iron-induced generation of mitochondrial ROS depends on AMPK activity[J]. BIOMETALS,2017,30(4):623-628.
APA	胡毅.,黄辉.,陈俊.,卢会茹.,周梦雪.,...&Hu, Y.(2017).Iron-induced generation of mitochondrial ROS depends on AMPK activity.BIOMETALS,30(4),623-628.
MLA	胡毅,et al."Iron-induced generation of mitochondrial ROS depends on AMPK activity".BIOMETALS 30.4(2017):623-628.