mTOR Signaling in Parkinson's Disease

doi:10.1007/s12017-016-8417-7

	mTOR Signaling in Parkinson's Disease
	Lan AP(兰爱平); Chai, ZF; Zhao, YL; Chen, J; Zhao YL(赵宇亮); Chai ZF(柴之芳); Hu Y(胡毅); Lan, AP; Chen J(陈俊); Hu, Y
刊名	NEUROMOLECULAR MEDICINE
	2017
卷号	19 期号:1 页码:1-10
关键词	mTOR Parkinson's disease Apoptosis alpha-Synuclein Oxidative stress
ISSN号	1535-1084
DOI	10.1007/s12017-016-8417-7
文献子类	Review
英文摘要	As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson's disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms underlying mTOR-mediated effects in PD have not been fully understood yet. Here, we review recent progress in characterizing the association of mTOR signaling with PD risk factors and further discuss the potential roles of mTOR in PD.
电子版国际标准刊号	1559-1174
WOS关键词	MUTANT ALPHA-SYNUCLEIN ; CENTRAL-NERVOUS-SYSTEM ; IN-VIVO MODELS ; OXIDATIVE STRESS ; DOPAMINERGIC-NEURONS ; MAMMALIAN TARGET ; NEURODEGENERATIVE DISEASES ; HYDROGEN-PEROXIDE ; PROTEIN-KINASE ; CELL-DEATH
WOS研究方向	Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000396029500001
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/284934]
专题	高能物理研究所_多学科研究中心高能物理研究所_实验物理中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Lan AP,Chai, ZF,Zhao, YL,et al. mTOR Signaling in Parkinson's Disease[J]. NEUROMOLECULAR MEDICINE,2017,19(1):1-10.
APA	兰爱平.,Chai, ZF.,Zhao, YL.,Chen, J.,赵宇亮.,...&Hu, Y.(2017).mTOR Signaling in Parkinson's Disease.NEUROMOLECULAR MEDICINE,19(1),1-10.
MLA	兰爱平,et al."mTOR Signaling in Parkinson's Disease".NEUROMOLECULAR MEDICINE 19.1(2017):1-10.