Hepatoprotective steroids from roots of Cynanchum otophyllum
Dong, Jinrun1,2,3; Peng, Xingrong1,3; Lu, Shuangyang1,2,3; Zhou, Lin1,3; Qiu, Minghua1,3
刊名FITOTERAPIA
2019-07-01
卷号136页码:7
关键词Cynanchum otophyllum Asclepiadaceae Steriods Anti-liver fibrosis activity
ISSN号0367-326X
DOI10.1016/j.fitote.2019.104171
通讯作者Qiu, Minghua(mhchiu@mail.kib.ac.cn)
英文摘要Seven undescribed C21 steroids, namely cynanchin A-G, together with thirteen known analogues, were isolated from the roots of cynanchum otophyllum. Their structures were elucidated by 1D, 2D NMR and MS spectra, as well as chemical methods. Meanwhile, all of isolates were tested for their anti-hepatic fibrosis activity. Among them, compounds 4-6, 10-12 and 14-17 showed moderate or significant inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-beta 1 (TGF-beta 1) in vitro.
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000474320500017
内容类型期刊论文
源URL[http://ir.kib.ac.cn/handle/151853/67951]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者Qiu, Minghua
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Dong, Jinrun,Peng, Xingrong,Lu, Shuangyang,et al. Hepatoprotective steroids from roots of Cynanchum otophyllum[J]. FITOTERAPIA,2019,136:7.
APA Dong, Jinrun,Peng, Xingrong,Lu, Shuangyang,Zhou, Lin,&Qiu, Minghua.(2019).Hepatoprotective steroids from roots of Cynanchum otophyllum.FITOTERAPIA,136,7.
MLA Dong, Jinrun,et al."Hepatoprotective steroids from roots of Cynanchum otophyllum".FITOTERAPIA 136(2019):7.
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