Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii

doi:10.1021/acs.orglett.9b01125

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii
	Zhan, Rui 1; Hu, You-Tian 2; Shao, Li-Dong 3; Qin, Xu-Jie4 ; Kuang, Fang 1; Du, Shou-Zhen 1; Wu, Fang 2; Chen, Ye-Gao 1
刊名	ORGANIC LETTERS
	2019-05-17
卷号	21 期号:10 页码:3678-3681
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b01125
通讯作者	Wu, Fang(fang.wu@sjtu.edu.cn) ; Chen, Ye-Gao(ygchen48@126.com)
英文摘要	Horisfieldones A (1) and B (2), two dimeric diarylpropanes featuring an unprecedentedly aromatic ring-contracted framework, were isolated from Horsfieldia kingii. Their structures and absolute configurations were determined by the inspection of extensive spectroscopic data and electronic circular dichroism calculations. Molecular modeling analysis, in vitro enzyme-based bioassays, and structure-activity relationship analysis of these isolates revealed that (+)-1 (IC50 = 35.1 +/- 3.9 mu M, SI > 11.4) could present a new class of human DOPA decarboxylase inhibitor.
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000468696100044
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/67525]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Wu, Fang; Chen, Ye-Gao
作者单位	1.Yunnan Normal Univ, Sch Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Minist Educ, Key Lab Syst Biomed, Shanghai 200240, Peoples R China 3.Yunnan Univ Chinese Med, Dept Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhan, Rui,Hu, You-Tian,Shao, Li-Dong,et al. Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii[J]. ORGANIC LETTERS,2019,21(10):3678-3681.
APA	Zhan, Rui.,Hu, You-Tian.,Shao, Li-Dong.,Qin, Xu-Jie.,Kuang, Fang.,...&Chen, Ye-Gao.(2019).Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii.ORGANIC LETTERS,21(10),3678-3681.
MLA	Zhan, Rui,et al."Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii".ORGANIC LETTERS 21.10(2019):3678-3681.