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	Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells
	Dong, Fa-Wu1; Li, Fang1; Ren, Jia-Jia1; Zhao, Cheng-Mei1; Diao, Hong-Li1; Li, Bao-Jing1; Li, Yan-Ping1; Hu, Jiang-Miao2; He, Hong-Ping1
刊名	NATURAL PRODUCT RESEARCH
	2019-04-25
页码	6
关键词	Valeriana amurensis sesquiterpenoids central nervous system PC12 cells
ISSN号	1478-6419
DOI	10.1080/14786419.2019.1603223
通讯作者	Hu, Jiang-Miao(hujiangmiao@mail.kib.ac.cn) ; He, Hong-Ping(95431111@qq.com)
英文摘要	Two new sesquiterpenoids, including a kessane-type sesquiterpenoid (1) and one bisabolane derivative (2), together with fourteen known sesquiterpenoids (3-16), were isolated from the roots and rhizomes of Valeriana amurensis. The structures of new compounds were established on the basis of extensive spectroscopic analysis. All isolates were evaluated for their effects on nerve growth factor (NGF)-mediated neurite outgrowth in pheochromocytoma (PC12) cells. As a results, four compounds including 10-12 and 15 showed potent promoting effects at the concentration of 10 mu M on NGF-induced neurite outgrowth in PC12 cells with the differentiation rate of 11.84%, 12.21%, 13.77% and 12.16%, respectively. [GRAPHICS] .
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000470405900001
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/67402]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Hu, Jiang-Miao; He, Hong-Ping
作者单位	1.Yunnan Univ Chinese Med, Coll Tradit Chinese Med, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Dong, Fa-Wu,Li, Fang,Ren, Jia-Jia,et al. Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells[J]. NATURAL PRODUCT RESEARCH,2019:6.
APA	Dong, Fa-Wu.,Li, Fang.,Ren, Jia-Jia.,Zhao, Cheng-Mei.,Diao, Hong-Li.,...&He, Hong-Ping.(2019).Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells.NATURAL PRODUCT RESEARCH,6.
MLA	Dong, Fa-Wu,et al."Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells".NATURAL PRODUCT RESEARCH (2019):6.

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