Molecular cloning, expression analysis and localization pattern of the MST family in grass carp (Ctenopharyngodon idella) | |
Chu, Pengfei1,2; He, Libo1; Xiong, Lv1,2; Luo, Lifei1,2; Huang, Rong1; Liao, Lanjie1; Li, Yongming1; Zhu, Zuoyan1; Wang, Yaping1 | |
刊名 | FISH & SHELLFISH IMMUNOLOGY |
2018-05-01 | |
卷号 | 76期号:1页码:316-323 |
关键词 | Mammalian sterile 20-like Immune regulation Subcellular localization Bimolecular fluorescence complementation |
ISSN号 | 1050-4648 |
DOI | 10.1016/j.fsi.2018.03.021 |
英文摘要 | The mammalian sterile 20-like (MST) family, which belongs to the serine/threonine protein kinase superfamily, has five members that can be found in mammals: STK3 (also called MST2), STK4 (MST1), STK24 (MST3), STK25 (YSK1 or SOK1), and STK26 (MST4). The MST kinases have key roles in apoptosis, immune regulation, inflammatory responses, cancer, and cell proliferation in mammals, whereas the roles and transcriptional regulatory mechanism of these kinases in teleost fish are still unclear. In this study, four STK genes (CiSTK3, CiSTK24, CiSTK25, and CiSTK26) were cloned and analyzed in grass carp (Ctenopharyngodon idella). All four STK genes were broadly expressed in the examined tissues, while their relative expression levels differed. In addition, after exposure to the grass carp reovirus, mRNA expression levels of the four STK genes were altered to different levels in the immune organs, and the levels were dramatically altered in the blood. Subcellular localization indicated that all four STK proteins were localized in the cytoplasm of transfected cells. Moreover, bimolecular fluorescence complementation analysis revealed that mouse protein-25 could interact with CiSTK3, CiSTK24, CiSTK25, and CiSTK26 independently in grass carp. Thus, our findings provide new insights for understanding the functions of the MST family in teleosts. |
资助项目 | National Natural Science Foundation of China[31721005] ; Hubei Natural Science Foundation of China[2015CFA007] ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science[XDA08030203] |
WOS关键词 | PROVIDES INSIGHTS ; KINASE MST1 ; APOPTOSIS ; PROTEIN ; MO25 ; ACTIVATION ; PHOSPHORYLATION ; REOVIRUS ; COMPLEX ; MECHANISM |
WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
语种 | 英语 |
出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000430888400038 |
资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Hubei Natural Science Foundation of China ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science ; Strategic Pilot Science and Technology Projects (A) Category, Chinese Academy of Science |
内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/30609] |
专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
通讯作者 | Wang, Yaping |
作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Chu, Pengfei,He, Libo,Xiong, Lv,et al. Molecular cloning, expression analysis and localization pattern of the MST family in grass carp (Ctenopharyngodon idella)[J]. FISH & SHELLFISH IMMUNOLOGY,2018,76(1):316-323. |
APA | Chu, Pengfei.,He, Libo.,Xiong, Lv.,Luo, Lifei.,Huang, Rong.,...&Wang, Yaping.(2018).Molecular cloning, expression analysis and localization pattern of the MST family in grass carp (Ctenopharyngodon idella).FISH & SHELLFISH IMMUNOLOGY,76(1),316-323. |
MLA | Chu, Pengfei,et al."Molecular cloning, expression analysis and localization pattern of the MST family in grass carp (Ctenopharyngodon idella)".FISH & SHELLFISH IMMUNOLOGY 76.1(2018):316-323. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论