Perfluorododecanoic acid exposure induced developmental neurotoxicity in zebrafish embryos | |
Guo, Xiaochun1; Zhang, Shengnan1,2; Lu, Shaoyong1; Zheng, Binghui1; Xie, Ping3; Chen, Jun3; Li, Guangyu4; Liu, Chunsheng4; Wu, Qin4; Cheng, Houcheng4 | |
刊名 | ENVIRONMENTAL POLLUTION |
2018-10-01 | |
卷号 | 241期号:1页码:1018-1026 |
关键词 | PFDoA Zebrafish embryo Acetylcholine Dopamine Developmental neurotoxicity |
ISSN号 | 0269-7491 |
DOI | 10.1016/j.envpol.2018.06.013 |
英文摘要 | Perfluorododecanoic acid (PFDoA), an artificial perfluorochemical, has been widely distributed in different ambient media and has been reported to have the potential to cause developmental neurotoxicity. However, the specific mechanism is largely unknown. In the current study, zebrafish embryos were treated with 0, 0.24, 1.2, and 6 mg/L PFDoA for 120 h. Exposure to PFDoA causes serious decreases in hatching delay, body length, as well as decreased locomotor speed in zebrafish larvae. Additionally, the acetylcholine (ACh) content as well as acetylcholinesterase (AChE) activity were determined to be significantly downregulated in PFDoA treatment groups. The level of dopamine was upregulated significantly after treating with 1.2 and 6 mg/L of PFDoA. Gene expressions related to the nervous system development were also analyzed, with the exception of the gene mesencephalic astrocyte-derived neurotrophic factor (manf), which is upregulated in the 6 mg/L treatment group. All other genes were significantly downregulated in larvae in the PFDoA group in different degrees. In general, the results demonstrated that PFDoA exposure could result in the disruption of the cholinergic system, dopaminergic signaling, and the central nervous system. (C) 2018 Elsevier Ltd. All rights reserved. |
资助项目 | National Natural Science Foundation of China (NSFC)[41601544] ; Ministry of Science and Technology of China[2015FY11-0900] |
WOS关键词 | PERFLUOROOCTANE SULFONATE PFOS ; THYROID ENDOCRINE DISRUPTION ; LARVAL ZEBRAFISH ; FLAME RETARDANTS ; DROSOPHILA-MELANOGASTER ; DANIO-RERIO ; PERFLUOROALKYL ACIDS ; LOCOMOTOR-ACTIVITY ; PROTEOMIC ANALYSIS ; NEONATAL EXPOSURE |
WOS研究方向 | Environmental Sciences & Ecology |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000440390800106 |
资助机构 | National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China |
内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/30578] |
专题 | 水生生物研究所_淡水生态学研究中心_期刊论文 |
通讯作者 | Lu, Shaoyong |
作者单位 | 1.Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Natl Engn Lab Lake Pollut Control & Ecol Restorat, SEPSORSLD, Beijing 100012, Peoples R China 2.Shanxi Univ, Coll Environm & Resource, Taiyuan 030006, Shanxi, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Hubei, Peoples R China 4.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Guo, Xiaochun,Zhang, Shengnan,Lu, Shaoyong,et al. Perfluorododecanoic acid exposure induced developmental neurotoxicity in zebrafish embryos[J]. ENVIRONMENTAL POLLUTION,2018,241(1):1018-1026. |
APA | Guo, Xiaochun.,Zhang, Shengnan.,Lu, Shaoyong.,Zheng, Binghui.,Xie, Ping.,...&Sang, Nan.(2018).Perfluorododecanoic acid exposure induced developmental neurotoxicity in zebrafish embryos.ENVIRONMENTAL POLLUTION,241(1),1018-1026. |
MLA | Guo, Xiaochun,et al."Perfluorododecanoic acid exposure induced developmental neurotoxicity in zebrafish embryos".ENVIRONMENTAL POLLUTION 241.1(2018):1018-1026. |
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