Comparative Proteomic Analysis of Lysine Acetylation in Fish CIK Cells Infected with Aquareovirus | |
Guo, Hong1; Zhang, Jie1,2; Wang, Yaping2; Bu, Chen3; Zhou, Yanyan3; Fang, Qin1 | |
刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
2017-11-01 | |
卷号 | 18期号:11页码:21 |
关键词 | comparative proteomics Ctenopharyngodon idella kidney cells aquareovirus infection lysine acetylation |
ISSN号 | 1422-0067 |
DOI | 10.3390/ijms18112419 |
英文摘要 | Grass carp (Ctenopharyngodon idellus) is an important worldwide commercial freshwater culture species. However, grass carp reovirus (GCRV) causes serious hemorrhagic disease in fingerlings and yearlings of fishes. To understand the molecular pathogenesis of host cells during GCRV infection, intensive proteomic quantification analysis of lysine acetylation in Ctenopharyngodon idella kidney (CIK) cells was performed. Using dimethylation labeling-based quantitative proteomics, 832 acetylated proteins with 1391 lysine acetylation sites were identified in response to GCRV infection, among which 792 proteins with 1323 sites were quantifiable. Bioinformatics analysis showed that differentially expressed lysine acetylated proteins are involved in diverse cellular processes and associated with multifarious functions, suggesting that extensive intracellular activities were changed upon viral infection. In addition, extensive alterations on host-protein interactions at the lysine acetylation level were also detected. Further biological experiments showed that the histone deacetylases (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) could significantly suppress the GCRV replication. To our knowledge, this is the first to reveal the proteome-wide changes in host cell acetylome with aquatic virus infection. The results provided in this study laid a basis for further understanding the host response to aquareovirus infection in the post-translational modification aspect by regulating cell lysine acetylation conducive to viral replication. |
资助项目 | National Natural Science Foundation of China[31372565] ; National Natural Science Foundation of China[31370190] ; National Natural Science Foundation of China[31672693] |
WOS关键词 | DISEASE VIRUS-INFECTION ; HUMAN OLIGODENDROGLIA CELLS ; HEAT-SHOCK PROTEINS ; HISTONE ACETYLTRANSFERASE ; INDUCED APOPTOSIS ; TREATMENT REVEALS ; CANCER ; IDENTIFICATION ; METABOLISM ; ACETYLOME |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
出版者 | MDPI AG |
WOS记录号 | WOS:000416811300191 |
资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/30129] |
专题 | 水生生物研究所_其他_期刊论文 |
通讯作者 | Fang, Qin |
作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 3.Jingjie PTM BioLab Hangzhou Co Ltd, Hangzhou 310018, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Guo, Hong,Zhang, Jie,Wang, Yaping,et al. Comparative Proteomic Analysis of Lysine Acetylation in Fish CIK Cells Infected with Aquareovirus[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(11):21. |
APA | Guo, Hong,Zhang, Jie,Wang, Yaping,Bu, Chen,Zhou, Yanyan,&Fang, Qin.(2017).Comparative Proteomic Analysis of Lysine Acetylation in Fish CIK Cells Infected with Aquareovirus.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(11),21. |
MLA | Guo, Hong,et al."Comparative Proteomic Analysis of Lysine Acetylation in Fish CIK Cells Infected with Aquareovirus".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.11(2017):21. |
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