| USP2a Supports Metastasis by Tuning TGF-beta Signaling | |
| Zhao, Yin1; Wang, Xiaomeng1,2; Wang, Qingqing3; Deng, Yu5; Li, Kang1,2; Zhang, Man1,2; Zhang, Qiang1,2; Zhou, Jin2; Wang, Hong-Yan2; Bai, Peng2 | |
| 刊名 | CELL REPORTS
 |
| 2018-02-27 | |
| 卷号 | 22期号:9页码:2442-2454 |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2018.02.007 |
| 英文摘要 | TGF-beta has been demonstrated to promote tumor metastasis, and the regulatory mechanisms are poorly understood. Here, we report the role of USP2a in promoting metastasis by facilitating TGF-beta-triggered signaling. USP2a interacts with TGFBR1 and TGFBR2 upon TGF-beta stimulation and removes K33-linked polyubiquitin chains from Lys502 of TGFBR1, promoting the recruitment of SMAD2/3. Simultaneously, TGFBR2 phosphorylates Ser207/Ser225 of USP2a, leading to the disassociation of SMAD2/3 from TGFBR1. The phosphorylation of USP2a and SMAD2 is positively correlated in human tumor biopsies, and USP2a is hyper-phosphorylated in lung adenocarcinomas with lymph node invasion. Depletion or pharmacologic inhibition of USP2a dampens TGF-beta-triggered signaling and metastasis. Our findings have characterized an essential role of USP2a as a potential target for treatment of metastatic cancers. |
| 资助项目 | Ministry of Science and Technology of China[2014CB542601] ; Natural Science Foundation of China[31521091] ; Natural Science Foundation of China[31601131] ; Natural Science Foundation of China[31671454] ; Natural Science Foundation of China[31622036] ; Wuhan University[2042017kf0199] ; Wuhan University[2042017kf0242] ; State Key Laboratory of Veterinary Etiological Biology[SKLVEB2017KFKT004] |
| WOS关键词 | UBIQUITIN-SPECIFIC PROTEASE ; CYCLIN D1 DEGRADATION ; I RECEPTOR ; PROSTATE-CANCER ; ACTIVATION ; GROWTH ; DOMAIN ; SMAD2 ; GLIOBLASTOMA ; RECOGNITION |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000426243000019 |
| 资助机构 | Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; Wuhan University ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology ; State Key Laboratory of Veterinary Etiological Biology |
| 内容类型 | 期刊论文 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/29916]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 通讯作者 | Zhong, Bo |
| 作者单位 | 1.Wuhan Univ, Sch Med, Med Res Inst, Wuhan 430071, Hubei, Peoples R China 2.Wuhan Univ, Coll Life Sci, Wuhan 430072, Hubei, Peoples R China 3.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China 4.Wuhan Univ, Renmin Hosp, Canc Ctr, Wuhan 430060, Hubei, Peoples R China 5.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Thorac Surg, Wuhan 430030, Hubei, Peoples R China 6.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept & Inst Infect Dis, Wuhan 430030, Hubei, Peoples R China 7.Wuhan Qlife Lab Co, Wuhan 430074, Hubei, Peoples R China 8.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yin,Wang, Xiaomeng,Wang, Qingqing,et al. USP2a Supports Metastasis by Tuning TGF-beta Signaling[J]. CELL REPORTS,2018,22(9):2442-2454. |
| APA | Zhao, Yin.,Wang, Xiaomeng.,Wang, Qingqing.,Deng, Yu.,Li, Kang.,...&Zhong, Bo.(2018).USP2a Supports Metastasis by Tuning TGF-beta Signaling.CELL REPORTS,22(9),2442-2454. |
| MLA | Zhao, Yin,et al."USP2a Supports Metastasis by Tuning TGF-beta Signaling".CELL REPORTS 22.9(2018):2442-2454. |
| 个性服务 |
| 查看访问统计 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论