Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector

doi:10.1016/S0021-9673(03)00653-8

CORC > 化学研究所 > 中国科学院化学研究所

	Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector
	Guo, L ; Lin, SJ ; Yang, YF ; Qi, L ; Wang, MX ; Chen, Y
刊名	JOURNAL OF CHROMATOGRAPHY A
	2003-05-23
卷号	998 期号:1-2 页码:221-228
关键词	Enantiomer Separation Arylglycine Amides Amides Cyclodextrins
ISSN号	0021-9673
DOI	10.1016/S0021-9673(03)00653-8
英文摘要	Nine racemic arylglycine amides were synthesized and successfully enantioseparated by capillary electrophoresis (CE) using highly sulfated beta-cyclodextrin (HS-beta-CD) as a chiral selector. Baseline enantioseparation of the analytes was obtained around neutral pH but not in the acidic conditions that are commonly used. HS-beta-CD content, buffer pH, type and concentration, and organic modifier concentration were studied and optimized for fast and efficient separation. A chiral CE separation system composed of 1.5% (w/v) HS-beta-CD, 0 to 10% (v/v) methanol and 20 mM 3-(N-morpholino)propanesulfonic acid at pH 6.5 was shown suitable for baseline enantioseparation of the mentioned amides within. 6 min, including simultaneous enantioseparation of three positional isomer series (methyl-, methoxyl or chloro-substituted). By using this system, D-enantionters migrated ahead of the L-enantiomers and the enantiomeric resolution order of arylglycine amides was more or less parallel to the pK(a) order of the analytes. (C) 2003 Elsevier Science B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000183589100020
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/80627]
专题	中国科学院化学研究所
通讯作者	Chen, Y
作者单位	1.Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Biol Chem Lab, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Guo, L,Lin, SJ,Yang, YF,et al. Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector[J]. JOURNAL OF CHROMATOGRAPHY A,2003,998(1-2):221-228.
APA	Guo, L,Lin, SJ,Yang, YF,Qi, L,Wang, MX,&Chen, Y.(2003).Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector.JOURNAL OF CHROMATOGRAPHY A,998(1-2),221-228.
MLA	Guo, L,et al."Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector".JOURNAL OF CHROMATOGRAPHY A 998.1-2(2003):221-228.