Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex

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	Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex
	Liu, JX ; Li, XP ; Wang, L ; Dong, Y ; Han, HW ; Liu, GQ
刊名	HEARING RESEARCH
	2003
卷号	175 期号:1-2 页码:45-53
关键词	Salicylate Tinnitus Inferior Colliculus Auditory Cortex 5-ht Microdialysis
ISSN号	0378-5955
英文摘要	In vivo microdialysis offers a unique approach to monitor biochemical events related to brain function and metabolism, and has been used extensively in many systems to measure the release of endogenous transmitters and other neuroactive substances during normal and pathological conditions. The characterization of neurotransmitters' changes induced by salicylate in the inferior colliculus (IC) and the auditory cortex (AC) may provide insight into the action of salicylate on the auditory system and, through this, provide a better understanding of neurological mechanism of salicylate-induced tinnitus. In the present study, the effect of salicylate on 5-HT system in IC and AC has been monitored by microdialysis in salicylate-induced tinnitus animal models. Glucose and lactate levels in IC and AC were significantly increased after application of salicylate (350 mg/kg, i.p.), indicating a salicylate-related increase in regional neuronal activity. The 5-HT level increased to a maximum of 268 +/- 27% basal level in IC 2 It after application and of 277 +/- 24% basal level in AC around 3 h after application. These data suggest that the increases of 5-HT levels in IC and AC may be involved in the tinnitus generation. (C) 2002 Elsevier Science B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000180567300005
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/80545]
专题	中国科学院化学研究所
通讯作者	Liu, JX
作者单位	1.Peking Univ, Dept Otorhinolaryngol, Third Hosp, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Liu, JX,Li, XP,Wang, L,et al. Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex[J]. HEARING RESEARCH,2003,175(1-2):45-53.
APA	Liu, JX,Li, XP,Wang, L,Dong, Y,Han, HW,&Liu, GQ.(2003).Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex.HEARING RESEARCH,175(1-2),45-53.
MLA	Liu, JX,et al."Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex".HEARING RESEARCH 175.1-2(2003):45-53.