Template effect of adenine-contained polymer nucleic acid analog on the coupled action of uridine by N-(O,O '-diisopropyl)phosphoryl alanine

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	Template effect of adenine-contained polymer nucleic acid analog on the coupled action of uridine by N-(O,O '-diisopropyl)phosphoryl alanine
	Xiang, HQ ; Hu, JJ ; Jiang, Y ; Yang, CD ; Zhao, YF ; Su, BL ; Wang, GH
刊名	CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
	2001-10-01
卷号	22 期号:10 页码:1672-1676
关键词	Phosphoryl Amino Acid Nucleoside Polymer Nucleic Acid Analog Template Effect
ISSN号	0251-0790
英文摘要	The effect of poly [beta-(N-7-adeninyl) ethyl methacrylate] on the reaction of uridine with N-(O,O'-diisopropyl)phosphoryl alanine was studied. It was found that the adenine-contained polymer nucleic acid analog acted as a template to accelerate the coupled action of uridine by phosphoryl alanine. In the presence of the nucleic acid analog, the yield of uridyl-nucleotides and uridyl-oligonucleotides were increased significantly. The template effect of poly [beta-(N-7-adeninyl) ethyl methacrylate] showed a selectivity to the coupled action of uridine but not the adenosine. In addition, since the skeleton polymethacrylate did not show any catalytic effect, the template effect of poly [beta-(N-7-adeninyl) ethyl methacrylate] must the due to the adenine-bonded side chain.
语种	英语
出版者	HIGHER EDUCATION PRESS
WOS记录号	WOS:000172051000016
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/77873]
专题	中国科学院化学研究所
通讯作者	Zhao, YF
作者单位	1.Tsing Hua Univ, Sch Life Sci & Engn, Dept Chem, Key Lab Bioorgan Phosphorus Chem Educ Minis, Beijing 100084, Peoples R China 2.Tsing Hua Univ, Sch Life Sci & Engn, Dept Chem, Anal Ctr, Beijing 100084, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Xiang, HQ,Hu, JJ,Jiang, Y,et al. Template effect of adenine-contained polymer nucleic acid analog on the coupled action of uridine by N-(O,O '-diisopropyl)phosphoryl alanine[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2001,22(10):1672-1676.
APA	Xiang, HQ.,Hu, JJ.,Jiang, Y.,Yang, CD.,Zhao, YF.,...&Wang, GH.(2001).Template effect of adenine-contained polymer nucleic acid analog on the coupled action of uridine by N-(O,O '-diisopropyl)phosphoryl alanine.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,22(10),1672-1676.
MLA	Xiang, HQ,et al."Template effect of adenine-contained polymer nucleic acid analog on the coupled action of uridine by N-(O,O '-diisopropyl)phosphoryl alanine".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 22.10(2001):1672-1676.