Degradation and 5-fluorouracil release behavior in vitro of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymer

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	Degradation and 5-fluorouracil release behavior in vitro of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymer
	Wang, SG; Chen, HL; Cai, Q; Bei, JZ
刊名	POLYMERS FOR ADVANCED TECHNOLOGIES
	2001-03-01
卷号	12 期号:3-4 页码:253-258
关键词	Polycaproloctone/poly(Ethylene Oxide)/polylactide Tri-component Copolymer Crystallinity Degradation Drug Controlled Release 5-fluorouracil
ISSN号	1042-7147
英文摘要	The in vitro degradation behavior of the polyester/polyether copolymer based on polycaprolactone/poly(ethylene oxide)/polylactide (PCEL) significantly depends on the caproxyl (CL)/lactyl (LA) ratio for the same poly(ethylene oxide) (PEO) content. The PCEL copolymer with rich CL units shows the crystalline structure of PCL with a slow degradation rate while it presents crystalline structure of poly-L-lactide (PLLA) with more LA units that has a fast degradation rate. In the case of PCEL with similar CL and LA unit contents, it only exhibits the crystalline structure of PEO and the degradation rate is faster especially during the early stage of the degradation due to the rapid cleavage of the PEG. The drug release system is prepared using 5-fluorouracil (5-Fu) as the model drug and PCEL copolymers as the drug carriers. It is shown that the drug release rate is controlled by the composition, morphology and properties of the PCEL copolymer. In particular, the PCEL copolymer with 70% LA units displays a near zero-order sustained release in about 60 days. Therefore these copolymers have potential application as a controlled 5-fluorouracil delivery system. Copyright (C) 2001 John Wiley & Sons, Ltd.
语种	英语
出版者	JOHN WILEY & SONS LTD
WOS记录号	WOS:000167190800014
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/77727]
专题	中国科学院化学研究所
通讯作者	Wang, SG
作者单位	Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Wang, SG,Chen, HL,Cai, Q,et al. Degradation and 5-fluorouracil release behavior in vitro of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymer[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2001,12(3-4):253-258.
APA	Wang, SG,Chen, HL,Cai, Q,&Bei, JZ.(2001).Degradation and 5-fluorouracil release behavior in vitro of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymer.POLYMERS FOR ADVANCED TECHNOLOGIES,12(3-4),253-258.
MLA	Wang, SG,et al."Degradation and 5-fluorouracil release behavior in vitro of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymer".POLYMERS FOR ADVANCED TECHNOLOGIES 12.3-4(2001):253-258.