Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a batch reactor

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	Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a batch reactor
	Xiu, GH ; Jiang, L ; Li, P
刊名	INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
	2000-11-01
卷号	39 期号:11 页码:4054-4062
ISSN号	0888-5885
英文摘要	The immobilized enzyme-catalyzed kinetic resolution of racemate in a batch reactor was studied theoretically. An exact solution was developed for a first-order reaction coupled with the intraparticle and external mass transfers. The time courses of substrate concentration and conversion as well as the purity and yield of the desired product were predicted by the exact solution, and the effects of the intraparticle and external mass-transfer resistances on the enzyme enantioselectivity were also quantitatively discussed. A simple approximate solution, taking into account the simultaneous reaction/external and intraparticle mass-transfer processes for the immobilized enzyme, was presented to predict the purity and yield of the desired product. For a competitive Michaelis-Menten kinetic resolution process, the effects of the competitive inhibitions of substrate and free water on the resolution process were analyzed by the orthogonal collocation method. The effectiveness factor and the effective enantiomeric ratio were predicted by the domain division method for the simplest case that the resolution process is at pseudo steady state and the inhibition effect, of free water can be neglected.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000165191400010
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/75733]
专题	中国科学院化学研究所
通讯作者	Xiu, GH
作者单位	1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 2.Shenyang Inst Chem Technol, Dept Chem Engn, Shenyang 110021, Peoples R China
推荐引用方式 GB/T 7714	Xiu, GH,Jiang, L,Li, P. Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a batch reactor[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,2000,39(11):4054-4062.
APA	Xiu, GH,Jiang, L,&Li, P.(2000).Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a batch reactor.INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,39(11),4054-4062.
MLA	Xiu, GH,et al."Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a batch reactor".INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 39.11(2000):4054-4062.