Loop and water effect on stability of intertriplex DNA

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	Loop and water effect on stability of intertriplex DNA
	Yang, LJ; Lee, IS; Wang, C; Li, Q; Bai, CL
刊名	JOURNAL OF MOLECULAR STRUCTURE
	1998-02-03
卷号	442 期号:1-3 页码:275-280
关键词	Intertriplex Dna Stability Molecular Mechanics Loop Water
ISSN号	0022-2860
英文摘要	Stability of four intratriplexes and one intertriplex influenced by loops and water have been investigated by molecular mechanics calculation. The four intratriplexes are 5'-d(TC)(6)-d(T)(m)-d(CT)(6)-d(C)(n)-d(AG)(6)-3' (m, n = 3 or 4), the corresponding intertripler is d(TC)(6)d(AG)(6).d(CT)(6) (., Watson-Crick hydrogen bond; , Hoogsteen hydrogen band). We studied in detail how loops and water would effect intra-and interstrand interactions of the five triplexes, respectively. The results showed that the existence of loops may have limited impact on the stability of the concerned triplex structures, regardless of water environment. In contrast, water molecules do have appreciable effects on tripler stability. Sugar conformations of the five triplexes were also discussed in this paper. The theoretical results are in good agreement with the FT-IR experiments. (C) 1998 Elsevier Science B.V.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000072445300030
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/74779]
专题	中国科学院化学研究所
通讯作者	Bai, CL
作者单位	Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Yang, LJ,Lee, IS,Wang, C,et al. Loop and water effect on stability of intertriplex DNA[J]. JOURNAL OF MOLECULAR STRUCTURE,1998,442(1-3):275-280.
APA	Yang, LJ,Lee, IS,Wang, C,Li, Q,&Bai, CL.(1998).Loop and water effect on stability of intertriplex DNA.JOURNAL OF MOLECULAR STRUCTURE,442(1-3),275-280.
MLA	Yang, LJ,et al."Loop and water effect on stability of intertriplex DNA".JOURNAL OF MOLECULAR STRUCTURE 442.1-3(1998):275-280.