Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors

doi:10.1016/j.bmc.2011.04.039

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	Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors
	Wu, Yiran 1,2; Chen, Zheng 1; Liu, Ying 1,2; Yu, Lanlan 1; Zhou, Lu 1; Yang, Suijia 1; Lai, Luhua 1,2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY
	2011-06-01
卷号	19 期号:11 页码:3361-3366
关键词	Quinoline-4-methyl Esters Human Nonpancreatic Secretory Phospholipase a(2) Inhibitor Synthesis Bioassay Molecular Model
ISSN号	0968-0896
DOI	10.1016/j.bmc.2011.04.039
英文摘要	A series of novel fused heterocycle methyl esters were designed and synthesized as human nonpancreatic secretory phospholipase A(2) (hnps-PLA(2)) competitive inhibitors. Among the 22 synthesized compounds, 17 quinoline-4-methyl esters displayed hnps-PLA(2) inhibition activity in the in vitro bioassay. The IC50 value for the best compound 3o was 1.5 mu M. The structure-inhibition-activity relationships of the compounds were studied using molecular docking. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000290955400007
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/73913]
专题	中国科学院化学研究所
通讯作者	Liu, Ying
作者单位	1.Peking Univ, Coll Chem & Mol Engn, BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China 2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Wu, Yiran,Chen, Zheng,Liu, Ying,et al. Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(11):3361-3366.
APA	Wu, Yiran.,Chen, Zheng.,Liu, Ying.,Yu, Lanlan.,Zhou, Lu.,...&Lai, Luhua.(2011).Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY,19(11),3361-3366.
MLA	Wu, Yiran,et al."Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY 19.11(2011):3361-3366.