Rutile TiO2 particles exert size and surface coating dependent retention and lesions on the murine brain

doi:10.1016/j.toxlet.2011.08.001

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	Rutile TiO2 particles exert size and surface coating dependent retention and lesions on the murine brain
	Zhang, Lili 2; Bai, Ru 2; Li, Bai 3; Ge, Cuicui 3; Du, Jiangfeng 3; Liu, Ying 2; Le Guyader, Laurent 2; Zhao, Yuliang 2,3; Wu, Yanchuan 4; He, Shida 4
刊名	TOXICOLOGY LETTERS
	2011-11-10
卷号	207 期号:1 页码:73-81
关键词	Tio2 Nanoparticles Surface Modification Shape Intranasal Instillation Neurotransmitter Secretion Nanomaterials Murine Brain Toxicity
ISSN号	0378-4274
DOI	10.1016/j.toxlet.2011.08.001
英文摘要	The rising commercial use and large-scale production of engineered nanoparticles (NPs) may lead to unintended exposure to humans. The central nervous system (CNS) is a potential susceptible target of the inhaled NPs, but so far the amount of studies on this aspect is limited. Here, we focus on the potential neurological lesion in the brain induced by the intranasally instilled titanium dioxide (TiO2) particles in rutile phase and of various sizes and surface coatings. Female mice were intranasally instilled with four different types of TiO2 particles (i.e. two types of hydrophobic particles in micro- and nano-sized without coating and two types of water-soluble hydrophilic nano-sized particles with silica surface coating) every other day for 30 days. Inductively coupled plasma mass spectrometry (ICP-MS) were used to determine the titanium contents in the sub-brain regions. Then, the pathological examination of brain tissues and measurements of the monoamine neurotransmitter levels in the sub-brain regions were performed. We found significant up-regulation of Ti contents in the cerebral cortex and striatum after intranasal instillation of hydrophilic TiO2 NPs. Moreover, TiO2 NPs exposure, in particular the hydrophilic NPs, caused obvious morphological changes of neurons in the cerebral cortex and significant disturbance of the monoamine neurotransmitter levels in the sub-brain regions studied. Thus, our results indicate that the surface modification of the NPs plays an important role on their effects on the brain. In addition, the difference in neurotoxicity of the two types of hydrophilic NPs may be induced by the shape differences of the materials. The present results suggest that physicochemical properties like size, shape and surface modification of the nanomaterials should be considered when evaluating their neurological effects. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000296177600010
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/73527]
专题	中国科学院化学研究所
通讯作者	Ma, Yongmei
作者单位	1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China 4.Xuanwu Hosp Capital Med Sci, Beijing Inst Geriatr, Dept Neurobiol, Beijing 100053, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Lili,Bai, Ru,Li, Bai,et al. Rutile TiO2 particles exert size and surface coating dependent retention and lesions on the murine brain[J]. TOXICOLOGY LETTERS,2011,207(1):73-81.
APA	Zhang, Lili.,Bai, Ru.,Li, Bai.,Ge, Cuicui.,Du, Jiangfeng.,...&Chen, Chunying.(2011).Rutile TiO2 particles exert size and surface coating dependent retention and lesions on the murine brain.TOXICOLOGY LETTERS,207(1),73-81.
MLA	Zhang, Lili,et al."Rutile TiO2 particles exert size and surface coating dependent retention and lesions on the murine brain".TOXICOLOGY LETTERS 207.1(2011):73-81.