Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions

doi:10.1021/la2038558

CORC > 化学研究所 > 中国科学院化学研究所

	Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions
	Dong, Zhixin; Mao, Jun; Yang, Muquan; Wang, Dapeng; Bo, Shuqin; Ji, Xiangling
刊名	LANGMUIR
	2011-12-20
卷号	27 期号:24 页码:15282-15291
ISSN号	0743-7463
DOI	10.1021/la2038558
英文摘要	Biocompatible and zwitterionic poly(sulfobetaine methacrylate) (PSBMA) was grafted onto the surface of initiator-modified silica nanopartides via surface-initiated atom transfer radical polymerization. The resultant samples were characterized via nuclear magnetic resonance, Fourier transform infrared spectroscopy, transmission electron microscopy, and thermogravimetric analysis. Their molecular weights and molecular weight distributions were determined via gel permeation chromatography after the removal of silica by etching. Moreover, the phase behavior of these polyzwitterionic-grafted silica nanoparticles in aqueous solutions and stability in protein/PBS solutions were systematically investigated. Dynamic light scattering and UV-visible spectroscopy results indicate that the silica-g-PSBMA nanoparticles exhibit an upper critical solution temperature (UCST) in aqueous solutions, which can be controlled by varying the PSBMA molecular weight, ionic strength, silica-g-PSBMA nanoparticle concentration, and solvent polarity. The UCSTs shift toward high temperatures with increasing PSBMA molecular weight and silica-g-PSBMA nanoparticle concentration. However, increasing the ionic strength and solvent polarity leads to a lowering of the UCSTs. The silica-g-PSBMA nanoparticles are stable for at least 72 h in both negative and positive protein/PBS solutions at 37 degrees C. The current study is crucial for the translation of polyzwitterionic solution behavior to surfaces to exploit their diverse properties in the development of new, smart, and responsive coatings.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000298118500068
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/73411]
专题	中国科学院化学研究所
通讯作者	Ji, Xiangling
作者单位	Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Grad Sch, Changchun 130022, Peoples R China
推荐引用方式 GB/T 7714	Dong, Zhixin,Mao, Jun,Yang, Muquan,et al. Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions[J]. LANGMUIR,2011,27(24):15282-15291.
APA	Dong, Zhixin,Mao, Jun,Yang, Muquan,Wang, Dapeng,Bo, Shuqin,&Ji, Xiangling.(2011).Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions.LANGMUIR,27(24),15282-15291.
MLA	Dong, Zhixin,et al."Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions".LANGMUIR 27.24(2011):15282-15291.