Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases

doi:10.1088/1674-0068/24/05/580-585

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	Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases
	Liu, Kun-hui; Wu, Li-dan; Zou, Xiao-ran; Yang, Wen; Du, Qian; Su, Hong-mei
刊名	CHINESE JOURNAL OF CHEMICAL PHYSICS
	2011-10-01
卷号	24 期号:5 页码:580-585
关键词	Tetrachlorobenzoquinone Thymine Uracil Triplet State Hydrogen Abstraction Electron Transfer Laser Flash Photolysis
ISSN号	1674-0068
DOI	10.1088/1674-0068/24/05/580-585
英文摘要	Pentachlorophenol, a widespread environmental pollutant that is possibly carcinogenic to humans, is metabolically oxidized to tetrachloroquinone (TCBQ) which can result in DNA damage. We have investigated the photochemical. reaction dynamics of TCBQ with two pyrimidine type nucleobases (thymine and uracil) upon UVA (355 nm) excitation using the technique of nanosecond time-resolved laser flash photolysis. It has been found that 355 nm excitation populates TCBQ molecules to their triplet state (3)TCBQ*, which are highly reactive towards thymine or uracil and undergo two parallel reactions, the hydrogen abstraction and electron transfer, leading to the observed photoproducts of TCBQH. and TCBQ.(-) in transient absorption spectra. The concomitantly produced nucleobase radicals and radical cations are expected to induce a series of oxidative or strand cleavage damage to DNA afterwards. By characterizing the photochemical hydrogen abstraction and electron transfer reactions, our results provide potentially important molecular reaction mechanisms for understanding the carcinogenic effects of pentachlorophenol and its metabolites TCBQ.
语种	英语
出版者	CHINESE PHYSICAL SOC
WOS记录号	WOS:000297139200012
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/73375]
专题	中国科学院化学研究所
通讯作者	Su, Hong-mei
作者单位	Chinese Acad Sci, State Key Lab Mol React Dynam, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Kun-hui,Wu, Li-dan,Zou, Xiao-ran,et al. Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases[J]. CHINESE JOURNAL OF CHEMICAL PHYSICS,2011,24(5):580-585.
APA	Liu, Kun-hui,Wu, Li-dan,Zou, Xiao-ran,Yang, Wen,Du, Qian,&Su, Hong-mei.(2011).Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases.CHINESE JOURNAL OF CHEMICAL PHYSICS,24(5),580-585.
MLA	Liu, Kun-hui,et al."Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases".CHINESE JOURNAL OF CHEMICAL PHYSICS 24.5(2011):580-585.