Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signal transduction

doi:10.1007/s11434-011-4415-1

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	Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signal transduction
	Yang Yong; Xia Tie; Zhang Wei; Fang XiaoHong
刊名	CHINESE SCIENCE BULLETIN
	2011-04-01
卷号	56 期号:11 页码:1063-1067
ISSN号	1001-6538
DOI	10.1007/s11434-011-4415-1
英文摘要	Fluorescence imaging of single molecules is becoming a powerful tool to examine biological processes at the molecular level. Using total internal reflection fluorescence microscopy (TIRFM), it has been possible to study the dynamic behavior of single molecules on living cell membranes. Herein, we briefly review the application of TIRFM-based single-molecule imaging in studies of membrane receptors involved in signal transduction. Furthermore, we discuss several examples of our own research on growth factor receptors, including TGF-beta receptors, HER2, and EGFR, and speculate possible applications of this technique to investigate other cellular events occurring on or near the plasma-membrane.
语种	英语
出版者	SCIENCE CHINA PRESS
WOS记录号	WOS:000289898600001
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/73237]
专题	中国科学院化学研究所
通讯作者	Fang XiaoHong
作者单位	Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Yang Yong,Xia Tie,Zhang Wei,et al. Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signal transduction[J]. CHINESE SCIENCE BULLETIN,2011,56(11):1063-1067.
APA	Yang Yong,Xia Tie,Zhang Wei,&Fang XiaoHong.(2011).Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signal transduction.CHINESE SCIENCE BULLETIN,56(11),1063-1067.
MLA	Yang Yong,et al."Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signal transduction".CHINESE SCIENCE BULLETIN 56.11(2011):1063-1067.