Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models

doi:10.1163/092050610X500570

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	Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models
	Wan, Yanhui 2; Zheng, Yonghui 1; Song, Xiangfu 3; Hu, Xiuli 1; Liu, Shi 1; Tong, Ti 2; Jing, Xiabin 1
刊名	JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
	2011
卷号	22 期号:9 页码:1131-1146
关键词	Lewis Lung Cancer Polymer-drug Conjugate Paclitaxel Folic Acid Targeted Drug Delivery Cell Apoptosis
ISSN号	0920-5063
DOI	10.1163/092050610X500570
英文摘要	Two kinds of paclitaxel (PTX) conjugate nanomicelles were prepared for cell apoptosis and anti-tumor activity evaluation on Lewis lung cancer mice models. One (PTX micelles) was prepared by self-assembling the PTX-conjugate co-polymer, poly(ethylene glycol)-b-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate/PTX), and the other (FA-PTX micelles) was by co-assembling a mixture of the folic acid (FA)-carrying co-polymer poly(ethylene glycol)-b-poly(L-lactide-co-2,2-dihydroxylmethyl-propylene carbonate/FA) (PEG-b-P(LA-co-DHP/FA)), and the PTX-conjugate co-polymer. At 7 and 14 days after tail intravenous injection, the mice were killed. The inhibition rates of tumor growth for PTX and FA-PTX micelles were 50 and 90%, respectively, on the day 7, and 33 and 71%, respectively, on the day 14 after drug injection. Flow cytometry analysis showed that the cell apoptosis rates were 43, 54 and 72% for the control group, PTX micelles group and FA-PTX micelles group, respectively, on the day 7, and 16, 25 and 42 on the day 14. With the TUNEL assay, the grey values of PTX micelles and FA-PTX micelles groups were determined to be 61-62% and 43-44%, of that of the control group, on day 7 or day 14, respectively. Therefore, the PTX micelles and the FA-PTX composite micelles significantly inhibited the subcutaneously inoculated Lewis lung cancer and effectively induced the cell apoptosis, and the FA-PTX composite micelles displayed a better efficacy than the PTX-micelles, implying the contribution of the folate-mediated targeting and endocytosis effect. (C) Koninklijke Brill NV, Leiden, 2011
语种	英语
出版者	VSP BV
WOS记录号	WOS:000288135600002
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/72151]
专题	中国科学院化学研究所
通讯作者	Jing, Xiabin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Jilin Univ, Hosp 1, Changchun 130021, Peoples R China 3.Jilin Univ, Sch Publ Hlth, Changchun 130021, Peoples R China
推荐引用方式 GB/T 7714	Wan, Yanhui,Zheng, Yonghui,Song, Xiangfu,et al. Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2011,22(9):1131-1146.
APA	Wan, Yanhui.,Zheng, Yonghui.,Song, Xiangfu.,Hu, Xiuli.,Liu, Shi.,...&Jing, Xiabin.(2011).Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models.JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,22(9),1131-1146.
MLA	Wan, Yanhui,et al."Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models".JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 22.9(2011):1131-1146.