High-sensitivity biosensors fabricated by tailoring the localized surface plasmon resonance property of core-shell gold nanorods

doi:10.1016/j.aca.2010.10.033

CORC > 化学研究所 > 中国科学院化学研究所

	High-sensitivity biosensors fabricated by tailoring the localized surface plasmon resonance property of core-shell gold nanorods
	Huang, Haowen 1; Huang, Shaowen 1; Yuan, Shishan 2; Qu, Caiting 1; Chen, Yi 3; Xu, Zhongjian 1; Liao, Bo 1; Zeng, Yunlong 1; Chu, Paul K.4
刊名	ANALYTICA CHIMICA ACTA
	2011-01-10
卷号	683 期号:2 页码:242-247
关键词	Localized Surface Plasmon Resonance Gold Nanorod Composite Schistosomiasis Japonica Biosensor
ISSN号	0003-2670
DOI	10.1016/j.aca.2010.10.033
英文摘要	An enhanced sensitive biosensor has been developed to detect biological targets by tailoring the localized surface plasmon resonance property of core-shell gold nanorods. In this new concept, a shell layer is produced on gold nanorods by generating a layer of chalcogenide on the gold nanorod surface after attachment of the recognition reagent, namely, goat IgG and antigen of schistosomiasis japonica. The bioactivity of these attached biomolecules is retained and the sensitivity of this biosensor is thus enhanced significantly. The plasmonic properties of the gold nanorods attached with the biomolecules can be adjusted and the plasmon resonance wavelength can be red-shifted up to several hundred nanometers in the visible or near infrared (NIR) region, which is extremely important to biosensing applications. This leads to a lager red-shift in the localized surface plasmon resonance absorption compared to the original gold nanorod-based sensor and hence offers greatly enhanced sensitivity in the detection of schistosomiasis japonica. The human serum infected with schistosomiasis japonica diluted to 1:50,000 (volume ratio, serum/buffer solution) can be detected readily. The technique offers enhanced sensitivity and can be easily extended to other sensing applications based on not only immuno-recognition but also other types of specific reactions. (C) 2010 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000286854700013
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/71493]
专题	中国科学院化学研究所
通讯作者	Huang, Haowen
作者单位	1.Hunan Univ Sci & Technol, Key Lab Theoret Chem & Mol Simulat, Minist Educ, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China 2.Hunan Normal Univ, Coll Med, Changsha 410013, Hunan, Peoples R China 3.Chinese Acad Sci, Key Lab Analyt Chem Living Biosyst, Inst Chem, Beijing 100190, Peoples R China 4.City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Huang, Haowen,Huang, Shaowen,Yuan, Shishan,et al. High-sensitivity biosensors fabricated by tailoring the localized surface plasmon resonance property of core-shell gold nanorods[J]. ANALYTICA CHIMICA ACTA,2011,683(2):242-247.
APA	Huang, Haowen.,Huang, Shaowen.,Yuan, Shishan.,Qu, Caiting.,Chen, Yi.,...&Chu, Paul K..(2011).High-sensitivity biosensors fabricated by tailoring the localized surface plasmon resonance property of core-shell gold nanorods.ANALYTICA CHIMICA ACTA,683(2),242-247.
MLA	Huang, Haowen,et al."High-sensitivity biosensors fabricated by tailoring the localized surface plasmon resonance property of core-shell gold nanorods".ANALYTICA CHIMICA ACTA 683.2(2011):242-247.