pH-dependent self-assembly of amphiphilic poly(L-glutamic acid)-block-poly(lactic-co-glycolic acid) copolymers

doi:10.1016/j.polymer.2010.04.008

CORC > 化学研究所 > 中国科学院化学研究所

	pH-dependent self-assembly of amphiphilic poly(L-glutamic acid)-block-poly(lactic-co-glycolic acid) copolymers
	Yang, Yanan 1,2; Cai, Jing 1,2; Zhuang, Xiuli 1; Guo, Zhaopei 1; Jing, Xiabin 1; Chen, Xuesi 1
刊名	POLYMER
	2010-05-28
卷号	51 期号:12 页码:2676-2682
关键词	Poly(L-lactic-co-glycolic Acid)-block-Poly(L-glutamic Acid) Macromolecular Coupling Reaction Ph Sensitivity
ISSN号	0032-3861
DOI	10.1016/j.polymer.2010.04.008
英文摘要	A novel biodegradable AB-type diblock copolymer poly(L-lactic-co-glycolic acid)-block-poly(L-glutamic acid) (PLGA-b-PGA) was synthesized by a macromolecular coupling reaction between carboxyl-terminated PLGA and amino-terminated poly(gamma-benzyl-glutamate) (PBLG) and the subsequent elimination of the protecting benzyl group. The structures of PLGA PGA and its precursors were confirmed by Fourier transform infrared spectroscopy (FT-IR), (1)H nuclear magnetic resonance ((1)H NMR) spectroscopy and gel permeation chromatography (GPC). This synthetic strategy simplified a former synthesis process of polypeptide-poly(L-lactic acid)(PLA); by using this new synthetic route the molecular weight and block ratio of PLGA PGA could be easily controlled by adjusting the chain length of PLGA/PGA. The pH sensitivity and self-assembly behavior of PLGA-PGA copolymer were investigated by environmental scanning electron microscopy (ESEM), transmission electron microscopy (TEM) and dynamic light scattering (DLS). The results showed that the copolymer exhibited high pH responses, and the morphologies of the copolymer aggregates underwent four stages orderly with the pH increase (pH = 3-9): a disorganized form, micelles, semi-vesicles with thick walls and vesicles. Such a pH-dependent self-assembly process of the copolymer is promising for drug control release and bio-applications. (c) 2010 Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000278188500030
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/70643]
专题	中国科学院化学研究所
通讯作者	Chen, Xuesi
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Changchun Univ Technol, Inst Chem Engn, Changchun 130012, Peoples R China
推荐引用方式 GB/T 7714	Yang, Yanan,Cai, Jing,Zhuang, Xiuli,et al. pH-dependent self-assembly of amphiphilic poly(L-glutamic acid)-block-poly(lactic-co-glycolic acid) copolymers[J]. POLYMER,2010,51(12):2676-2682.
APA	Yang, Yanan,Cai, Jing,Zhuang, Xiuli,Guo, Zhaopei,Jing, Xiabin,&Chen, Xuesi.(2010).pH-dependent self-assembly of amphiphilic poly(L-glutamic acid)-block-poly(lactic-co-glycolic acid) copolymers.POLYMER,51(12),2676-2682.
MLA	Yang, Yanan,et al."pH-dependent self-assembly of amphiphilic poly(L-glutamic acid)-block-poly(lactic-co-glycolic acid) copolymers".POLYMER 51.12(2010):2676-2682.