Internalization, Translocation and Biotransformation of Silica-Coated Titanium Dioxide Nanoparticles in Neural Stem Cells

doi:10.1166/jnn.2010.2824

CORC > 化学研究所 > 中国科学院化学研究所

	Internalization, Translocation and Biotransformation of Silica-Coated Titanium Dioxide Nanoparticles in Neural Stem Cells
	Wang, Yanli 1; Wang, Jia 1; Wu, Minghong 1; Deng, Xiaoyong 1; Wen, Tieqiao 2; Chen, Chunying 4; Zhang, Haijiao 1; Liu, Yuanfang 1,3; Jiao, Zheng 1
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2010-11-01
卷号	10 期号:11 页码:7121-7125
关键词	Internalization Translocation Titanium Dioxide Nanoparticles Biotransformation Neural Stem Cells
ISSN号	1533-4880
DOI	10.1166/jnn.2010.2824
英文摘要	Nanotechnology has gained massive applications in the fields of biology and pharmacology. Recently, more research attention has been paid to explore the interaction between nanoparticles (NPs) and cells, in particular, the entry of NPs into cells. Herein, we focus on the internalization of the FITC-labeled silica-coated titania NPs (FITC-TiO2@SiO2 NPs) in neural stem cells (NSCs) and their subsequent translocation. Various microscopic techniques, such as confocal-laser-scanning microscopy (CFLSM), transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used to track the time-dependent pathway of NPs in cells. It was found that NPs traversed cell membrane and localized around the cell nucleus. Most NPs congregated in lysosomes and were transformed by lysosomes after 48 h co-incubation.
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000283621300027
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/69887]
专题	中国科学院化学研究所
通讯作者	Liu, Yuanfang
作者单位	1.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China 2.Shanghai Univ, Inst Syst Biol, Shanghai 200444, Peoples R China 3.Peking Univ, Beijing Natl Lab Mol Sci, Dept Biol Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 4.Natl Ctr Nanosci & Technol, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yanli,Wang, Jia,Wu, Minghong,et al. Internalization, Translocation and Biotransformation of Silica-Coated Titanium Dioxide Nanoparticles in Neural Stem Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(11):7121-7125.
APA	Wang, Yanli.,Wang, Jia.,Wu, Minghong.,Deng, Xiaoyong.,Wen, Tieqiao.,...&Jiao, Zheng.(2010).Internalization, Translocation and Biotransformation of Silica-Coated Titanium Dioxide Nanoparticles in Neural Stem Cells.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(11),7121-7125.
MLA	Wang, Yanli,et al."Internalization, Translocation and Biotransformation of Silica-Coated Titanium Dioxide Nanoparticles in Neural Stem Cells".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.11(2010):7121-7125.