Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study

doi:10.1007/s10856-008-3672-2

CORC > 化学研究所 > 中国科学院化学研究所

	Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study
	Xu, Xiaoyi 3; Liu, Tongjun 2; Liu, Shaohui 2; Zhang, Kai 2; Shen, Zhen 2; Li, Yuxin 3; Jing, Xiabin 1
刊名	JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
	2009-05-01
卷号	20 期号:5 页码:1167-1173
ISSN号	0957-4530
DOI	10.1007/s10856-008-3672-2
英文摘要	The current study investigates the feasibility of using a biodegradable polymeric stent in common bile duct (CBD) repair and reconstruction. Here, poly(l-lactide-co-glycolide) (PLGA, molar ratio LA/GA = 80/20) was processed into a circular tube- and dumbbell-shaped specimens to determine the in vitro degradation behavior in bile. The morphology, weight loss, and molecular weight changes were then investigated in conjunction with evaluations of the mechanical properties of the specimen. Circular tube-shaped PLGA stents with X-ray opacity were subsequently used in common bile duct exploration (CBDE) and primary suturing in canine models. Next, X-ray images of CBD stents in vivo were compared and levels of serum liver enzymes and a histological analysis were conducted after stent transplantation. The results showed that the PLGA stents exhibited the required biomedical properties and spontaneously disappeared from CBDs in 4-5 weeks. The degradation period and function match the requirements in repair and reconstruction of CBDs to support the duct, guide bile drainage, and reduce T-tube-related complications.
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000264837700017
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/68479]
专题	中国科学院化学研究所
通讯作者	Jing, Xiabin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Jilin Univ, Hosp 1, Dept Gen Surg, Changchun 130021, Peoples R China 3.NE Normal Univ, Minist Educ, Res Ctr Agr & Med Gene Engn, Natl Engn Lab Druggable Gene & Prot Screening, Changchun 130024, Peoples R China
推荐引用方式 GB/T 7714	Xu, Xiaoyi,Liu, Tongjun,Liu, Shaohui,et al. Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2009,20(5):1167-1173.
APA	Xu, Xiaoyi.,Liu, Tongjun.,Liu, Shaohui.,Zhang, Kai.,Shen, Zhen.,...&Jing, Xiabin.(2009).Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,20(5),1167-1173.
MLA	Xu, Xiaoyi,et al."Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 20.5(2009):1167-1173.