Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells

doi:10.1016/j.apradiso.2008.12.003

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	Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells
	Chu, Taiwei 1; Xu, Hong 1; Yang, Zhi 2,3; Wang, Xiangyun 1
刊名	APPLIED RADIATION AND ISOTOPES
	2009-04-01
卷号	67 期号:4 页码:590-593
关键词	(99m)Tc Complex Hypoxia Marker Lipophilicity Hydroxamamide Labeling
ISSN号	0969-8043
DOI	10.1016/j.apradiso.2008.12.003
英文摘要	Three new hydroxamamide derivatives with different lipophilicity, N'-hydroxy-N-methyl-3-(4-nitro-1H-imidazol-1-yl)propanamidine, N-butyl-N'-hydroxy-3-(4-nitro-1H-imidazol-1-yl)propanamidine, and N'-hydroxy-3-(4-nitro-1H-imidazol-1-yl)-N-octadecyl propanamidine were easily synthesized and labeled with technetium-99m as markers for hypoxic cells. The results of in vitro experiment indicate that the accumulation of three (99m)Tc-complexes steadily increases with time in hypoxic cells, but fluctuates with time and has no fixed trend in aerobic cells; the complex with higher lipophilicity shows more uptake in cells; and the effect of lipophilicity of the (99m)Tc-complexes on the hypoxic/aerobic difference can be neglected. (C) 2009 Elsevier Ltd. All rights reserved.
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000264305500017
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/67027]
专题	中国科学院化学研究所
通讯作者	Chu, Taiwei
作者单位	1.Peking Univ, BNLMS, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Peking Univ, Sch Oncol, Beijing 100036, Peoples R China 3.Peking Univ, Beijing Inst Canc Res, Beijing 100036, Peoples R China
推荐引用方式 GB/T 7714	Chu, Taiwei,Xu, Hong,Yang, Zhi,et al. Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells[J]. APPLIED RADIATION AND ISOTOPES,2009,67(4):590-593.
APA	Chu, Taiwei,Xu, Hong,Yang, Zhi,&Wang, Xiangyun.(2009).Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells.APPLIED RADIATION AND ISOTOPES,67(4),590-593.
MLA	Chu, Taiwei,et al."Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells".APPLIED RADIATION AND ISOTOPES 67.4(2009):590-593.