Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)

doi:10.1002/mabi.200800158

CORC > 化学研究所 > 中国科学院化学研究所

	Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)
	Hu, Xiuli 1,2; Chen, Xuesi 1; Wei, Jizheng 1,2; Liu, Shi 1; Jing, Xiabin 1
刊名	MACROMOLECULAR BIOSCIENCE
	2009-05-13
卷号	9 期号:5 页码:456-463
关键词	Biodegradable Core Crosslinking Drug Delivery Systems Polycarbonates Self-assembly
ISSN号	1616-5187
DOI	10.1002/mabi.200800158
英文摘要	A biodegradable amphiphilic block copolymer, PEG-b-P(LA-co-MAC), was used to prepare spherical micelles consisting of a hydrophobic P(LA-co-MAC) core and a hydrophilic PEG shell. To improve their stability, the micelles were crosslinked by radical polymerization of the double bonds in the hydrophobic blocks. The crosslinked micelles had similar sizes and a narrow size distribution compared to their uncrosslinked precursor. The improved stability of the crosslinked micelles was confirmed by measurements of the CMC and a thermodynamic investigation. These micelles can internalize into Hela cells in vitro as demonstrated by inverted fluorescence microscopy and CLSM. These stabilized nanoscale micelles have potential use in biomedical applications such as drug delivery and disease diagnosis.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000266456200007
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/66449]
专题	中国科学院化学研究所
通讯作者	Jing, Xiabin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Hu, Xiuli,Chen, Xuesi,Wei, Jizheng,et al. Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)[J]. MACROMOLECULAR BIOSCIENCE,2009,9(5):456-463.
APA	Hu, Xiuli,Chen, Xuesi,Wei, Jizheng,Liu, Shi,&Jing, Xiabin.(2009).Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate).MACROMOLECULAR BIOSCIENCE,9(5),456-463.
MLA	Hu, Xiuli,et al."Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)".MACROMOLECULAR BIOSCIENCE 9.5(2009):456-463.