Protein-responsive imprinted polymers with specific shrinking and rebinding

doi:10.1002/jmr.870

CORC > 化学研究所 > 中国科学院化学研究所

	Protein-responsive imprinted polymers with specific shrinking and rebinding
	Chen, Zhiyong; Hua, Zhendong; Xu, Li; Huang, Yong; Zhao, Meiping; Li, Yuanzong
刊名	JOURNAL OF MOLECULAR RECOGNITION
	2008
卷号	21 期号:1 页码:71-77
关键词	Molecularly Imprinted Polymer (Mip) Hydrogel Specific Shrinking Protein Recognition
ISSN号	0952-3499
DOI	10.1002/jmr.870
英文摘要	Stimuli-responsive protein imprinted polymers were obtained via a combination of molecular imprinting and reversible stimuli-responsive polymer using lysozyme or cytochrome c as template, N-isopropylacrylamide (NIPA) as major monomer, methacrylic acid (MAA) and acrylamide (AAm) as functional co-monomers, and N,N-methylenebisacrylamide (MBAAm) as crosslinker. The molecularly imprinted polymers (MIPs) can respond not only to external stimuli such as temperature and salt concentration, but also to the corresponding template protein with significant specific volume shrinking. This specific shrinking behavior was attributed to the synergistic effect of multiple-site weak interactions (electrostatic force, hydrogen bonding and hydrophobic interaction) and the cavity effect. The MIPs showed highly selective adsorption of template proteins with specific shrinking compared with the non-imprinted polymers. The results indicated that the MIPs seemed to change shape to accommodate the conformation of the template protein leading to the formation of a shape complementary cavity. Copyright (c) 2008 John Wiley & Sons, Ltd.
语种	英语
出版者	JOHN WILEY & SONS LTD
WOS记录号	WOS:000253689800008
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/65635]
专题	中国科学院化学研究所
通讯作者	Zhao, Meiping
作者单位	Peking Univ, Coll Chem & Mol Engn, Key Lab Bioorgan Chem & Mol Engn, BNLMS, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Chen, Zhiyong,Hua, Zhendong,Xu, Li,et al. Protein-responsive imprinted polymers with specific shrinking and rebinding[J]. JOURNAL OF MOLECULAR RECOGNITION,2008,21(1):71-77.
APA	Chen, Zhiyong,Hua, Zhendong,Xu, Li,Huang, Yong,Zhao, Meiping,&Li, Yuanzong.(2008).Protein-responsive imprinted polymers with specific shrinking and rebinding.JOURNAL OF MOLECULAR RECOGNITION,21(1),71-77.
MLA	Chen, Zhiyong,et al."Protein-responsive imprinted polymers with specific shrinking and rebinding".JOURNAL OF MOLECULAR RECOGNITION 21.1(2008):71-77.