Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water

doi:10.1002/marc.200800494

CORC > 化学研究所 > 中国科学院化学研究所

	Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water
	Zhao, Changwen 1,2; Zhuang, Xiuli 1; He, Chaoliang 1; Chen, Xuesi 1; Jing, Xiabin 1
刊名	MACROMOLECULAR RAPID COMMUNICATIONS
	2008-11-19
卷号	29 期号:22 页码:1810-1816
关键词	Hydrophilic Polymers Ph Responsive Polypeptide Self-assembly Temperature Responsive
ISSN号	1022-1336
DOI	10.1002/marc.200800494
英文摘要	A series of novel temperature and pH responsive block copolymers composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(L-lysine) (PLL) were synthesized. The effect of pH and the length of PLL on the lower critical solution temperature (LCST) of PNIPAM, and the self-assembly of these PLL-based copolymers induced by temperature and pH changes were investigated by the cloud point method, dynamic light scattering (DLS) and environmental scanning electron microscopy (ESEM). These PNIPAM-b-PLL copolymers can self-assemble into micelle-like aggregates with PNIPAM as the hydrophobic block at acidic pH and high temperatures; and at alkaline pH and low hey can self-assemble into temperatures, particles with PLL as the hydrophobic block. The copolymers may have potential applications in biotechnological and biomedical areas as drug release carriers.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000261544700005
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/64509]
专题	中国科学院化学研究所
通讯作者	Zhuang, Xiuli
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Changwen,Zhuang, Xiuli,He, Chaoliang,et al. Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water[J]. MACROMOLECULAR RAPID COMMUNICATIONS,2008,29(22):1810-1816.
APA	Zhao, Changwen,Zhuang, Xiuli,He, Chaoliang,Chen, Xuesi,&Jing, Xiabin.(2008).Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water.MACROMOLECULAR RAPID COMMUNICATIONS,29(22),1810-1816.
MLA	Zhao, Changwen,et al."Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water".MACROMOLECULAR RAPID COMMUNICATIONS 29.22(2008):1810-1816.