The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning | |
Xu, Xiuling4; Chen, Xuesi; Ma, Ping'an2; Wang, Xinri3; Jing, Xiabin1 | |
刊名 | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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2008-09-01 | |
卷号 | 70期号:1页码:165-170 |
关键词 | Emulsion Electrospinning Nanofiber Drug Delivery Diffusion |
ISSN号 | 0939-6411 |
DOI | 10.1016/j.ejpb.2008.03.010 |
英文摘要 | The release behavior of a water-soluble small molecule drug from the drug-loaded nanofibers prepared by emulsion-electrospinning was investigated. Doxorubicin hydrochloride (Dox), a water-soluble anticancer agent, was used as the model drug. The laser scanning confocal microscopic images indicated that the drug was well incorporated into amphiphilic poly(ethylene glycol)-poly(L-lactic acid) (PEG-PLA) diblock copolymer nanofibers, forming "core-sheath" structured drug-loaded nanofibers. The drug release behavior of this drug-loaded system showed a three-stage diffusion-controlled mechanism, in which the release rate of the first stage was slower than that of the second stage, but both obeyed Fick's second law. Based on these results, it is concluded that the Dox-loaded fibers prepared by emulsion-electrospinning represent a reservoir-type delivery system in which the Dox release rate decreases with the increasing Dox content in the fibers. (c) 2008 Elsevier B.V. All rights reserved. |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE BV |
WOS记录号 | WOS:000259742600018 |
内容类型 | 期刊论文 |
源URL | [http://ir.iccas.ac.cn/handle/121111/64099] ![]() |
专题 | 中国科学院化学研究所 |
通讯作者 | Jing, Xiabin |
作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.NE Normal Univ, Sch Life Sci, Changchun, Peoples R China 3.Jilin Univ, Minist Educ, Key Lab Zoonosis, Changchun 130023, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Xu, Xiuling,Chen, Xuesi,Ma, Ping'an,et al. The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning[J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,2008,70(1):165-170. |
APA | Xu, Xiuling,Chen, Xuesi,Ma, Ping'an,Wang, Xinri,&Jing, Xiabin.(2008).The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,70(1),165-170. |
MLA | Xu, Xiuling,et al."The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning".EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 70.1(2008):165-170. |
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