The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning

doi:10.1016/j.ejpb.2008.03.010

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	The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning
	Xu, Xiuling 4; Chen, Xuesi ; Ma, Ping'an 2; Wang, Xinri 3; Jing, Xiabin 1
刊名	EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
	2008-09-01
卷号	70 期号:1 页码:165-170
关键词	Emulsion Electrospinning Nanofiber Drug Delivery Diffusion
ISSN号	0939-6411
DOI	10.1016/j.ejpb.2008.03.010
英文摘要	The release behavior of a water-soluble small molecule drug from the drug-loaded nanofibers prepared by emulsion-electrospinning was investigated. Doxorubicin hydrochloride (Dox), a water-soluble anticancer agent, was used as the model drug. The laser scanning confocal microscopic images indicated that the drug was well incorporated into amphiphilic poly(ethylene glycol)-poly(L-lactic acid) (PEG-PLA) diblock copolymer nanofibers, forming "core-sheath" structured drug-loaded nanofibers. The drug release behavior of this drug-loaded system showed a three-stage diffusion-controlled mechanism, in which the release rate of the first stage was slower than that of the second stage, but both obeyed Fick's second law. Based on these results, it is concluded that the Dox-loaded fibers prepared by emulsion-electrospinning represent a reservoir-type delivery system in which the Dox release rate decreases with the increasing Dox content in the fibers. (c) 2008 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000259742600018
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/64099]
专题	中国科学院化学研究所
通讯作者	Jing, Xiabin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.NE Normal Univ, Sch Life Sci, Changchun, Peoples R China 3.Jilin Univ, Minist Educ, Key Lab Zoonosis, Changchun 130023, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xu, Xiuling,Chen, Xuesi,Ma, Ping'an,et al. The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning[J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,2008,70(1):165-170.
APA	Xu, Xiuling,Chen, Xuesi,Ma, Ping'an,Wang, Xinri,&Jing, Xiabin.(2008).The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,70(1),165-170.
MLA	Xu, Xiuling,et al."The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning".EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 70.1(2008):165-170.