Interaction of copolymer-paclitexal conjugate micelles with C-6 glioma cells

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	Interaction of copolymer-paclitexal conjugate micelles with C-6 glioma cells
	Wang Zhan-Feng 2; Luo Yi-Nan 2; Zheng Yong-Hui 1; Han Hai-Ling ; Hong Xin-Yu 2; Jing Xia-Bin 1
刊名	CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
	2008-08-01
卷号	29 期号:8 页码:1671-1676
关键词	Paclitaxel Conjugate Poly (Ethylene)-b-Poly (Lactic Acid) Block coPolymer Flow Cytometry Tem Clsm Glioma C-6 Cells Apoptosis Cell Cycle
ISSN号	0251-0790
英文摘要	Nanoscale micelles of poly(ethylene)-b-poly(lactic acid)/paclitexal conjugate (PEG-PLA/PTX) were prepared and their interaction with rat brain glioma C, cells was examined by MTT, electron microscopy, flow cytometry(FCM), and confocal laser scanning microscopy(CLSM). The results show that the copolymer paclitaxel conjugate micelles can enter the cell, and are distributed in cytoplasm. The paclitaxel call be released the conjugate micelles can react with the genes in the cell nuclei, causing changes in the gene molecules, and thus, leading to changes in growth cycle of the cells, resulting in G(2)-M cell cycle arrest and inducing apoptosis of C-6 cells. Therefore, PEG-PLA/PTX micelles may be used in chemotherapy of brain glioma.
语种	英语
出版者	HIGHER EDUCATION PRESS
WOS记录号	WOS:000258807300038
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/63875]
专题	中国科学院化学研究所
通讯作者	Jing Xia-Bin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Jilin Univ, Clin Hosp 1, Dept Neurosurg, Changchun 130021, Peoples R China
推荐引用方式 GB/T 7714	Wang Zhan-Feng,Luo Yi-Nan,Zheng Yong-Hui,et al. Interaction of copolymer-paclitexal conjugate micelles with C-6 glioma cells[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(8):1671-1676.
APA	Wang Zhan-Feng,Luo Yi-Nan,Zheng Yong-Hui,Han Hai-Ling,Hong Xin-Yu,&Jing Xia-Bin.(2008).Interaction of copolymer-paclitexal conjugate micelles with C-6 glioma cells.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,29(8),1671-1676.
MLA	Wang Zhan-Feng,et al."Interaction of copolymer-paclitexal conjugate micelles with C-6 glioma cells".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 29.8(2008):1671-1676.