A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation

doi:10.1002/app.28900

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	A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation
	Xie, Zhigang 1,2; Hu, Xiuli 1,2; Chen, Xuesi 1; Lu, Tiancheng 1,2; Liu, Shi 1; Jing, Xiabin 1
刊名	JOURNAL OF APPLIED POLYMER SCIENCE
	2008-12-05
卷号	110 期号:5 页码:2961-2970
关键词	Biodegradable Block Copolymers Docetaxel Rgd
ISSN号	0021-8995
DOI	10.1002/app.28900
英文摘要	A diblcok copolymer monomethoxy poly (ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate) (MPEG-b-P(LA-co-MCC)) was obtained by copolymerization of L-lactide (LA) and 2-methyl-2-benzoxycarbonyl-propylene carbonate (MBC) and subsequent catalytic hydrogenation. The pendant carboxyl groups of the copolymer MPEG-b-P(LA-co-MCC) were conjugated with antitumor drug docetaxel and tripeptide arginine-glycine-aspartic acid (RGD), respectively. H-1-NMR spectra confirmed the structure of the copolymer MPEG-b-P(LA-co-MCC/docetaxel) and MPEG-b-P(LA-co-MCC/RGD). In vitro antitumor assay indicates that the MPEG-b-P(LA-co-MCC/docetaxel) conjugate shows high cytotoxic activity against HeLa cancer cells. Cell adhesion and spreading experiment shows that copolymer MPEG-b-P(LA-co-MCC/RGD) is of benefit to cell adherence and is a promising biodegradable material for cell and tissue engineering. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 110: 2961-2970,2008
语种	英语
出版者	JOHN WILEY & SONS INC
WOS记录号	WOS:000260102800057
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/63171]
专题	中国科学院化学研究所
通讯作者	Jing, Xiabin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Xie, Zhigang,Hu, Xiuli,Chen, Xuesi,et al. A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2008,110(5):2961-2970.
APA	Xie, Zhigang,Hu, Xiuli,Chen, Xuesi,Lu, Tiancheng,Liu, Shi,&Jing, Xiabin.(2008).A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation.JOURNAL OF APPLIED POLYMER SCIENCE,110(5),2961-2970.
MLA	Xie, Zhigang,et al."A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation".JOURNAL OF APPLIED POLYMER SCIENCE 110.5(2008):2961-2970.