Preparation of molecularly imprinted monolith for trimethoprim molecule and its chromatographic property

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	Preparation of molecularly imprinted monolith for trimethoprim molecule and its chromatographic property
	Liu Xiang-Jun; Liu Ji-Zhong; Zhao Rui; Liu Guo-Quan; Chen Yi
刊名	CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
	2007-10-01
卷号	28 期号:10 页码:1878-1880
关键词	Molecularly Imprinted Polymer Monolith Trimethoprim
ISSN号	0251-0790
英文摘要	A monolithic molecularly imprinted polymer ( monolithic MIP) for trimethoprim ( TMP) was prepared by in situ polymerization method as the HPLC stationary phase. Methacrylic acid( MAA) and ethylene glycol dimethacrylate ( EDMA) were used as functional monomer and cross-linker, respectively. The obtained MIP monoliths were characterized by high performance liquid chromatography and scanning electron microscope. The SEM analysis result clearly shows that many macropores and flow-through pores were embedded in the network skeleton of the TMP-imprinted monolith, which allowed the mobile phase to flow through the monolithic MlPs with a very low flow resistance. When the flow rate was high to 9. 0 mL/min, the backpressure was only 11. 1 MPa. Moreover, the imprinting factor was up to 10. 3, which demonstrates that the obtained monolithic MIP showed a strong affinity and selectivity to the template molecule.
语种	英语
出版者	HIGHER EDUCATION PRESS
WOS记录号	WOS:000250324400017
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/61763]
专题	中国科学院化学研究所
通讯作者	Zhao Rui
作者单位	Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Liu Xiang-Jun,Liu Ji-Zhong,Zhao Rui,et al. Preparation of molecularly imprinted monolith for trimethoprim molecule and its chromatographic property[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2007,28(10):1878-1880.
APA	Liu Xiang-Jun,Liu Ji-Zhong,Zhao Rui,Liu Guo-Quan,&Chen Yi.(2007).Preparation of molecularly imprinted monolith for trimethoprim molecule and its chromatographic property.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,28(10),1878-1880.
MLA	Liu Xiang-Jun,et al."Preparation of molecularly imprinted monolith for trimethoprim molecule and its chromatographic property".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 28.10(2007):1878-1880.