Selective deprotection of N-Boc catalyzed by silica gel

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	Selective deprotection of N-Boc catalyzed by silica gel
	Zhang Min-Jie 1,2; Yuan Xiu-Hua 1; Ma Li 1; Zhao Jian-Ying 1; Gao Lian-Xun 1
刊名	CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
	2007-12-10
卷号	28 期号:12 页码:2330-2332
关键词	N-boc Deprotection Silica Gel Selective Deprotection
ISSN号	0251-0790
英文摘要	As an important protective group of amines and amino acids, tert-butoxycarbonyl(Boc) group was extensively used in organic synthesis. Though many mild and selective reagents could be used, there is still a need for the development of a more simple and convenient method for deprotection. In this paper, a new method for the deprotection of N-Boc group with silica gel in refluxing toluene was reported. The reactions were mostly achieved in 5 h with high yields (75% - 98%). N-Boc protected indoline and benzylamine, which are not deprotected with other mild method, could be deprotected with our method in good yields(89% and 95%, respectively). Additionally the deprotection of other carbamates such as Cbz, Fmoc and ethyl carbamate wasn't observed under same conditions.
语种	英语
出版者	HIGHER EDUCATION PRESS
WOS记录号	WOS:000251953400023
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/61247]
专题	中国科学院化学研究所
通讯作者	Gao Lian-Xun
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang Min-Jie,Yuan Xiu-Hua,Ma Li,et al. Selective deprotection of N-Boc catalyzed by silica gel[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2007,28(12):2330-2332.
APA	Zhang Min-Jie,Yuan Xiu-Hua,Ma Li,Zhao Jian-Ying,&Gao Lian-Xun.(2007).Selective deprotection of N-Boc catalyzed by silica gel.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,28(12),2330-2332.
MLA	Zhang Min-Jie,et al."Selective deprotection of N-Boc catalyzed by silica gel".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 28.12(2007):2330-2332.