Electrospun hydroxypropyl methyl cellulose phthalate (HPMCM/Erythromycin fibers for targeted release in intestine

doi:10.1002/app.25666

CORC > 化学研究所 > 中国科学院化学研究所

	Electrospun hydroxypropyl methyl cellulose phthalate (HPMCM/Erythromycin fibers for targeted release in intestine
	Wang, Meng ; Wang, Linge ; Huang, Yong
刊名	JOURNAL OF APPLIED POLYMER SCIENCE
	2007-11-15
卷号	106 期号:4 页码:2177-2184
关键词	Electrospinning Fibers Hydroxypropyl Methylcellulose Phthalate Composites Drug Delivery Systems
ISSN号	0021-8995
DOI	10.1002/app.25666
英文摘要	Ultrafine fiber mats of hydroxypropyl methyl cellulose phthalate (HPMCP) were successfully electrospun and explored as drug delivery vehicles using erythromycin as a model drug. The morphology of the electrospun fiber and the drug release process in the artificial gastric juice and in the artificial intestinal juice were investigated. With the same drug-to-matrix ratio (HPMCP/erythromycin = 9/1.), all the fibers were electrospun into a tape-like or ribbon shape and the average fiber diameter (AFD) was increased with the HPMCP concentration. Because of the pH-sensitive property of HPMCP, erythromycin was released from the erythromycin-containing electrospun HPMCP fiber mats by a slowly diffusion process in the artificial gastric juice, while it was released in nearly first-order kinetics in the artificial intestinal juice because of the first-order kinetics dissolution of the HPMCP fibers in the artificial intestinal juice. And the rate of erythromycin released in the artificial intestinal juice was about more than 2.5 times faster than that in the artificial gastric juice. The diameter of the fibers plays an important role on the rate and the total amount of the drug released both in stomach and in intestine, the rate and the total amount of the drug released decreasing with increasing AFD. (c) 2007 Wiley Periodicals, Inc.
语种	英语
出版者	JOHN WILEY & SONS INC
WOS记录号	WOS:000249590700004
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/60953]
专题	中国科学院化学研究所
通讯作者	Wang, Linge
作者单位	1.Chinese Acad Sci, Guangzhou Inst Chem, Key Lab Cellulose & Lignocellulos Chem, Guangzhou 510650, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Wang, Meng,Wang, Linge,Huang, Yong. Electrospun hydroxypropyl methyl cellulose phthalate (HPMCM/Erythromycin fibers for targeted release in intestine[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2007,106(4):2177-2184.
APA	Wang, Meng,Wang, Linge,&Huang, Yong.(2007).Electrospun hydroxypropyl methyl cellulose phthalate (HPMCM/Erythromycin fibers for targeted release in intestine.JOURNAL OF APPLIED POLYMER SCIENCE,106(4),2177-2184.
MLA	Wang, Meng,et al."Electrospun hydroxypropyl methyl cellulose phthalate (HPMCM/Erythromycin fibers for targeted release in intestine".JOURNAL OF APPLIED POLYMER SCIENCE 106.4(2007):2177-2184.