Monolithic molecularly imprinted polymer for sulfamethoxazole and molecular recognition properties in aqueous mobile phase

doi:10.1016/j.aca.2006.05.005

CORC > 化学研究所 > 中国科学院化学研究所

	Monolithic molecularly imprinted polymer for sulfamethoxazole and molecular recognition properties in aqueous mobile phase
	Liu, Xiangjun; Ouyan, Canbin; Zhao, Rui; Shangguan, Dihua; Chen, Yi; Liu, Guoquan
刊名	ANALYTICA CHIMICA ACTA
	2006-07-07
卷号	571 期号:2 页码:235-241
关键词	Molecularly Imprinted Polymer Monolithic Aqueous Phase Recognition Sulfamethoxazole Pharmaceutical Analysis
ISSN号	0003-2670
DOI	10.1016/j.aca.2006.05.005
英文摘要	A monolithic molecularly imprinted polymer (monolithic MIP) for sulfamethoxazole (SMO) was prepared by in situ polymerization method as the HPLC stationary phase. By optimizing the polymerization conditions. the monolithic MIP showed highly specific recognition for the template SMO over its three structurally related analogs. As shown by SEM and the pore size distribution profile, the resultant MIP monolith showed a main pore diameter of 594 nm and a large specific surface area of 124 m(2) g(-1), this allowed the mobile phase to flow through the column with low backpressure. Furthermore, the recognition abilities of the monolithic MIP in aqueous and organic media were studied. The results exhibited that the monolithic MIP possessed excellent recognition ability in aqueous media. Hydrophobic interactions. in addition to shape recognition, were the dominant effect for recognition in the mobile phase with high water content. Moreover. the binding sites and the dissociation constant were also determined by frontal chromatography as 122 mu mol g(-1) and 1.88 x 10(-5) mol L(-1), respectively. which demonstrated that the obtained SMO-MIP monolith had a high binding capacity and strong affinity ability to the template molecule. Furthermore. the resultant SMO-MIP monolith was used as HPLC column directly to determine the SMO contents in three kinds of pharmaceutical tablets with the optimized aqueous mobile phase. (c) 2006 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000238904500011
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/59831]
专题	中国科学院化学研究所
通讯作者	Zhao, Rui
作者单位	Chinese Acad Sci, Beijing Natl Lab Mol Sci, Lab Analyt Chem Life Sci, Inst Chem, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xiangjun,Ouyan, Canbin,Zhao, Rui,et al. Monolithic molecularly imprinted polymer for sulfamethoxazole and molecular recognition properties in aqueous mobile phase[J]. ANALYTICA CHIMICA ACTA,2006,571(2):235-241.
APA	Liu, Xiangjun,Ouyan, Canbin,Zhao, Rui,Shangguan, Dihua,Chen, Yi,&Liu, Guoquan.(2006).Monolithic molecularly imprinted polymer for sulfamethoxazole and molecular recognition properties in aqueous mobile phase.ANALYTICA CHIMICA ACTA,571(2),235-241.
MLA	Liu, Xiangjun,et al."Monolithic molecularly imprinted polymer for sulfamethoxazole and molecular recognition properties in aqueous mobile phase".ANALYTICA CHIMICA ACTA 571.2(2006):235-241.