Preparation of poly(lactide-co-glycolide-co-caprolactone) nanoparticles and their degradation behaviour in aqueous solution

doi:10.1016/j.polymdegradstab.2006.03.004

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	Preparation of poly(lactide-co-glycolide-co-caprolactone) nanoparticles and their degradation behaviour in aqueous solution
	Zhang, Hanwei; Cui, Wenjin; Bei, Jianzhong; Wang, Shenguo
刊名	POLYMER DEGRADATION AND STABILITY
	2006-09-01
卷号	91 期号:9 页码:1929-1936
关键词	Nanoparticles Poly(Lactide-co-glycolide-co-caprolactone) Spontaneous Emulsification Solvent Diffusion Method (Sesm Method) In Vitro Degradation
ISSN号	0141-3910
DOI	10.1016/j.polymdegradstab.2006.03.004
英文摘要	The tri-component copolymer poly(lactide-co-glycolide-co-caprolactone) (PLGC) was synthesized to prepare nanoparticles by the modifiedspontaneous emulsification solvent diffusion method (modified-SESD method); and the method was also modified by using the Tween60 instead of poly(vinyl alcohol) (PVA) as dispersing agent. The obtained nanoparticles have spherical shape and good particle distribution with mean size in the range from 100 to 200 nm. The in vitro degradation behaviour of PLGC nanoparticles was investigated. It was found that PLGC nanoparticles could remain stable during the degradation with no agglomeration. Compared with PLA and PLGA nanoparticles, the degradation rate of PLGC nanoparticles is faster. After 9 weeks of hydrolysis, the M. of PLGC is less by 10% of the original M-n. The mean radius of the nanoparticles increases from 68 nm to 80 nm continuously during the first stage, and after 4 weeks of degradation, the particles' size decreases gradually from 80 nm to about 40 nm. These results suggest that the PLGC nanoparticles may show degradation-controlled drug release behaviour and seem to be a promising drug delivery system. (c) 2006 Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000238918200003
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/59451]
专题	中国科学院化学研究所
通讯作者	Wang, Shenguo
作者单位	Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Inst Chem, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hanwei,Cui, Wenjin,Bei, Jianzhong,et al. Preparation of poly(lactide-co-glycolide-co-caprolactone) nanoparticles and their degradation behaviour in aqueous solution[J]. POLYMER DEGRADATION AND STABILITY,2006,91(9):1929-1936.
APA	Zhang, Hanwei,Cui, Wenjin,Bei, Jianzhong,&Wang, Shenguo.(2006).Preparation of poly(lactide-co-glycolide-co-caprolactone) nanoparticles and their degradation behaviour in aqueous solution.POLYMER DEGRADATION AND STABILITY,91(9),1929-1936.
MLA	Zhang, Hanwei,et al."Preparation of poly(lactide-co-glycolide-co-caprolactone) nanoparticles and their degradation behaviour in aqueous solution".POLYMER DEGRADATION AND STABILITY 91.9(2006):1929-1936.