Poly(L,L-lactide-co-glycolide)/tricalcium phosphate composite scaffold and its various changes during degradation in vitro

doi:10.1016/j.polymdegradstab.2006.08.008

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	Poly(L,L-lactide-co-glycolide)/tricalcium phosphate composite scaffold and its various changes during degradation in vitro
	Yang, Fei ; Cui, Wenjin ; Xiong, Zhuo ; Liu, Li ; Bei, Jianzhong ; Wang, Shenguo
刊名	POLYMER DEGRADATION AND STABILITY
	2006-12-01
卷号	91 期号:12 页码:3065-3073
关键词	Plga(70/30)/tcp Composite Scaffold Manufacturing Degradation Mechanical Property Bone Tissue Engineering
ISSN号	0141-3910
DOI	10.1016/j.polymdegradstab.2006.08.008
英文摘要	A poly(L,L-lactide-co-glycolide) (70/30)/(tricalcium phosphate) (PLGA/TCP) composite scaffold was fabricated by low-temperature deposition (LDM) and its degradation performed in vitro for 22 weeks. Various changes during degradation in vitro, which included changes in acidity of the degradation medium, morphology, weight, composition, molecular weight of the PLGA component and mechanical properties of the scaffold, were investigated. It was found that the acidity of degradation medium of the PLGA(70/30)/TCP composite scaffolds reduced and became much lower than that of TCP-free scaffold. With degradation, the volume and porosity of the PLGA(70/30)/TCP composite scaffold reduced at first then increased slowly, while the surface morphology of the scaffold changed from smooth to rough. The weight loss of the scaffold increased by dissolution of the degraded products and TCP component, but mainly by dissolution of the glycyl-rich degraded products of the PLGA component. The molecular weight of the PLGA component reduced with time, but the molecular weight distribution increased at first and then reduced. The compressive strength and modulus of the scaffold increased at first and then reduced with further degradation. The effect of degradation on modulus was much bigger than that on compressive strength. Based on excellent cell affinity of the PLGA(70/30)/FCP composite scaffold, a potentially useful bone tissue engineering scaffold is proposed. (c) 2006 Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000243088200029
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/59161]
专题	中国科学院化学研究所
通讯作者	Wang, Shenguo
作者单位	1.Chinese Acad Sci, Inst Chem, BNLMS, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China 3.Tsing Hua Univ, Dept Mech Engn, Beijing 100084, Peoples R China
推荐引用方式 GB/T 7714	Yang, Fei,Cui, Wenjin,Xiong, Zhuo,et al. Poly(L,L-lactide-co-glycolide)/tricalcium phosphate composite scaffold and its various changes during degradation in vitro[J]. POLYMER DEGRADATION AND STABILITY,2006,91(12):3065-3073.
APA	Yang, Fei,Cui, Wenjin,Xiong, Zhuo,Liu, Li,Bei, Jianzhong,&Wang, Shenguo.(2006).Poly(L,L-lactide-co-glycolide)/tricalcium phosphate composite scaffold and its various changes during degradation in vitro.POLYMER DEGRADATION AND STABILITY,91(12),3065-3073.
MLA	Yang, Fei,et al."Poly(L,L-lactide-co-glycolide)/tricalcium phosphate composite scaffold and its various changes during degradation in vitro".POLYMER DEGRADATION AND STABILITY 91.12(2006):3065-3073.