Porcine-derived xenogeneic bone/poly(glycolide-co-lactide-co-caprolactone) composite and its affinity with rat OCT-1 osteoblast-like cells

doi:10.1016/j.biomaterials.2005.05.101

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	Porcine-derived xenogeneic bone/poly(glycolide-co-lactide-co-caprolactone) composite and its affinity with rat OCT-1 osteoblast-like cells
	Qu, X; Wan, YQ; Zhang, HW; Cui, WJ; Bei, JZ; Wang, SG
刊名	BIOMATERIALS
	2006
卷号	27 期号:2 页码:216-225
关键词	Porcine-derived Xenogeneic Bone Pglc Composite Osteoblast-like Cell Cell Affinity Surface Topography
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2005.05.101
英文摘要	Porcine-derived xenogeneic bone (PDXB) was derived from cancellous bone of adult porcine. Its morphology and structure were characterized by SEM, FTIR and XRD. A series of composite films consisting of PDXB and poly(glycolide-co-lactide-cocaprolactone) (PGLC) polymer were prepared. Because of the introduction of PGLC polymer, the PDXB/PGLC composites especially PDXB/PGLC(30/70) and PDXB/PGLC(50/50) showed good processability and mechanical properties. In addition, the hydrophilicity of the composites was enhanced as well since the PDXB component was hydrophilic. Osteoblast-like cells (OCT-1) were used as an in-vitro model to assess the affinity of the PDXB/PGLC composites. It was found that compared with the pure PGLC film, PDXB/PGLC(30/70) and PDXB/PGLC(50/50) composite films promoted cell attachment, proliferation and ALP (alkaline phosphatase) activity obviously. In addition, the cells preferred growing on the areas of exposed PDXB. It was considered that the hydrophilicity, osteoconductivity and appropriate surface roughness (Sa = 3.30, 4.00 mu m) induced by PDXB facilitate cell growth. However, the introduction of too much PDXB, such as PDXB/PGLC(70/30) film, would obtain an adverse effect on the cell growth since the value of S-a was up to 7.33 mu m. It indicated that only the composites with appropriate surface topography could favor cell growth. Surface topography probably has a more important effect on cell growth process than surface chemistry. (c) 2005 Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000232517900010
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/58341]
专题	中国科学院化学研究所
通讯作者	Wang, SG
作者单位	Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Qu, X,Wan, YQ,Zhang, HW,et al. Porcine-derived xenogeneic bone/poly(glycolide-co-lactide-co-caprolactone) composite and its affinity with rat OCT-1 osteoblast-like cells[J]. BIOMATERIALS,2006,27(2):216-225.
APA	Qu, X,Wan, YQ,Zhang, HW,Cui, WJ,Bei, JZ,&Wang, SG.(2006).Porcine-derived xenogeneic bone/poly(glycolide-co-lactide-co-caprolactone) composite and its affinity with rat OCT-1 osteoblast-like cells.BIOMATERIALS,27(2),216-225.
MLA	Qu, X,et al."Porcine-derived xenogeneic bone/poly(glycolide-co-lactide-co-caprolactone) composite and its affinity with rat OCT-1 osteoblast-like cells".BIOMATERIALS 27.2(2006):216-225.