Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation

doi:10.1016/j.j.conrel.2005.02.024

CORC > 化学研究所 > 中国科学院化学研究所

	Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation
	Zeng, J ; Yang, LX ; Liang, QZ ; Zhang, XF ; Guan, HL ; Xu, XL ; Chen, XS ; Jing, XB
刊名	JOURNAL OF CONTROLLED RELEASE
	2005-06-20
卷号	105 期号:1-2 页码:43-51
关键词	Drug Delivery Electrospinning Ultrafine Fibers Compatibility Paclitaxel Doxorubicin Doxorubicin Hydrochloride Plla
ISSN号	0168-3659
DOI	10.1016/j.j.conrel.2005.02.024
英文摘要	The electrospun fiber mat for drug delivery is a novel formulation with promising clinical applications in the future. The influence of the solubility and compatibility of drugs in the drug/polymer/solvent system on the encapsulation of the drug inside the poly(L-lactide) (PLLA) electrospun fibers and the release behavior of this formulation were examined by using paclitaxel, doxorubicin hydrochloride and doxorubicin base as model drugs. The burst release of the drugs can be avoided by using compatible drugs with polymers, and the drug release can follow nearly zero-order kinetics due to the degradation of the PLLA fibers in the presence of proteinase K. (c) 2005 Elsevier B.V All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000230576600005
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/57647]
专题	中国科学院化学研究所
通讯作者	Jing, XB
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Shenyang Normal Univ, Dept Chem & Life Sci, Shenyang 110034, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shenyang 110034, Peoples R China
推荐引用方式 GB/T 7714	Zeng, J,Yang, LX,Liang, QZ,et al. Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation[J]. JOURNAL OF CONTROLLED RELEASE,2005,105(1-2):43-51.
APA	Zeng, J.,Yang, LX.,Liang, QZ.,Zhang, XF.,Guan, HL.,...&Jing, XB.(2005).Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation.JOURNAL OF CONTROLLED RELEASE,105(1-2),43-51.
MLA	Zeng, J,et al."Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation".JOURNAL OF CONTROLLED RELEASE 105.1-2(2005):43-51.