Synthesis and characterization of biodegradable amphiphilic triblock copolymers containing L-glutamic acid units | |
Guan, HL; Xie, ZG; Zhang, PB; Deng, C; Chen, XS; Jing, XB | |
刊名 | BIOMACROMOLECULES
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2005-07-01 | |
卷号 | 6期号:4页码:1954-1960 |
ISSN号 | 1525-7797 |
DOI | 10.1021/bm0492069 |
英文摘要 | A novel biodegradable amphiphilic triblock copolymer bearing pendant carboxyl groups PLGG-PEG-PLGG was successfully prepared by ring-opening copolymerization Of L-lactide (LA) with (3s)-benzoxylcarbonylethyl-morpholine-2, 5-dione (BEMD) in the presence of dihydroxyl poly(ethylene glycol) (PEG) as a macroinitiator in bulk at 130 degrees C using SnOct(2) as catalyst and by subsequent catalytic hydrogenation. The copolymer could form micelles in aqueous solution with the cmc dependent on the composition of the copolymer. The micelles exhibited a homogeneous spherical morphology and a unimodal size distribution. Their degradation rate in the presence of proteinase K was faster than that of PLA, and they showed a low degree of cytotoxicity to the articular cartilage cells. This biodegradable amphiphilic block copolymer with pendant carboxyl groups is capable of further modification and is expected to facilitate a variety of potential biomedical applications, such as drug carriers, tissue engineering, etc. |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000230498400021 |
内容类型 | 期刊论文 |
源URL | [http://ir.iccas.ac.cn/handle/121111/57505] ![]() |
专题 | 中国科学院化学研究所 |
通讯作者 | Jing, XB |
作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 13022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
推荐引用方式 GB/T 7714 | Guan, HL,Xie, ZG,Zhang, PB,et al. Synthesis and characterization of biodegradable amphiphilic triblock copolymers containing L-glutamic acid units[J]. BIOMACROMOLECULES,2005,6(4):1954-1960. |
APA | Guan, HL,Xie, ZG,Zhang, PB,Deng, C,Chen, XS,&Jing, XB.(2005).Synthesis and characterization of biodegradable amphiphilic triblock copolymers containing L-glutamic acid units.BIOMACROMOLECULES,6(4),1954-1960. |
MLA | Guan, HL,et al."Synthesis and characterization of biodegradable amphiphilic triblock copolymers containing L-glutamic acid units".BIOMACROMOLECULES 6.4(2005):1954-1960. |
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