Synthesis and characterization of biodegradable amphiphilic triblock copolymers containing L-glutamic acid units

doi:10.1021/bm0492069

CORC > 化学研究所 > 中国科学院化学研究所

	Synthesis and characterization of biodegradable amphiphilic triblock copolymers containing L-glutamic acid units
	Guan, HL ; Xie, ZG ; Zhang, PB ; Deng, C ; Chen, XS ; Jing, XB
刊名	BIOMACROMOLECULES
	2005-07-01
卷号	6 期号:4 页码:1954-1960
ISSN号	1525-7797
DOI	10.1021/bm0492069
英文摘要	A novel biodegradable amphiphilic triblock copolymer bearing pendant carboxyl groups PLGG-PEG-PLGG was successfully prepared by ring-opening copolymerization Of L-lactide (LA) with (3s)-benzoxylcarbonylethyl-morpholine-2, 5-dione (BEMD) in the presence of dihydroxyl poly(ethylene glycol) (PEG) as a macroinitiator in bulk at 130 degrees C using SnOct(2) as catalyst and by subsequent catalytic hydrogenation. The copolymer could form micelles in aqueous solution with the cmc dependent on the composition of the copolymer. The micelles exhibited a homogeneous spherical morphology and a unimodal size distribution. Their degradation rate in the presence of proteinase K was faster than that of PLA, and they showed a low degree of cytotoxicity to the articular cartilage cells. This biodegradable amphiphilic block copolymer with pendant carboxyl groups is capable of further modification and is expected to facilitate a variety of potential biomedical applications, such as drug carriers, tissue engineering, etc.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000230498400021
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/57505]
专题	中国科学院化学研究所
通讯作者	Jing, XB
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 13022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Guan, HL,Xie, ZG,Zhang, PB,et al. Synthesis and characterization of biodegradable amphiphilic triblock copolymers containing L-glutamic acid units[J]. BIOMACROMOLECULES,2005,6(4):1954-1960.
APA	Guan, HL,Xie, ZG,Zhang, PB,Deng, C,Chen, XS,&Jing, XB.(2005).Synthesis and characterization of biodegradable amphiphilic triblock copolymers containing L-glutamic acid units.BIOMACROMOLECULES,6(4),1954-1960.
MLA	Guan, HL,et al."Synthesis and characterization of biodegradable amphiphilic triblock copolymers containing L-glutamic acid units".BIOMACROMOLECULES 6.4(2005):1954-1960.