Rapid and efficient chiral separation of nateglinide and its L-enantiomer on monolithic molecularly imprinted polymers

doi:10.1016/j.chroma.2005.06.078

CORC > 化学研究所 > 中国科学院化学研究所

	Rapid and efficient chiral separation of nateglinide and its L-enantiomer on monolithic molecularly imprinted polymers
	Yin, JF ; Yang, GL ; Chen, Y
刊名	JOURNAL OF CHROMATOGRAPHY A
	2005-10-07
卷号	1090 期号:1-2 页码:68-75
关键词	Molecularly Imprinted Polymer Monolithic Column Chiral Separation Chiral Stationary Phases Nateglinide
ISSN号	0021-9673
DOI	10.1016/j.chroma.2005.06.078
英文摘要	A monolithic molecularly imprinted polymer (monolithic MIP) was designed and prepared for chiral separation of nateglinide and its L-enantiomer. The enantiomers were rapidly separated on this novel monolithic MIP based chiral stationary phase (MIP-CSP), whereas the enantioseparation was not obtained on the non-imprinted polymer (NIP). Chiral recognition was found to be dependent on the stereo structures and the arrangement of functional groups of the imprinted molecule and the cavities on MIP. Thermodynamic data (Delta Delta H and Delta Delta S) obtained by Van't Hoff plots revealed an enthalpy-controlled enantioseparation. The binding capacity was evaluated by frontal analysis. Monolithic nateglinide-MIP had an effective number of binding sites B-t = 41.15 mu mol g(-1) with a dissociation constant of K-d = 7.40 mM. The morphological characteristics of the monolithic MIP were investigated by pore analysis and scanning electron microscope (SEM). Results showed that both mesopores and macropores were formed in the monolith. Over all, this study presents a new and practical possibility for providing high rates of mass transfer, fast separations and high efficiencies without the pressure constraints of the traditional bulk molecularly imprinted polymers, through the monolithic MIPs. (c) 2005 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000231781100006
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/56829]
专题	中国科学院化学研究所
通讯作者	Yang, GL
作者单位	1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China 2.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China
推荐引用方式 GB/T 7714	Yin, JF,Yang, GL,Chen, Y. Rapid and efficient chiral separation of nateglinide and its L-enantiomer on monolithic molecularly imprinted polymers[J]. JOURNAL OF CHROMATOGRAPHY A,2005,1090(1-2):68-75.
APA	Yin, JF,Yang, GL,&Chen, Y.(2005).Rapid and efficient chiral separation of nateglinide and its L-enantiomer on monolithic molecularly imprinted polymers.JOURNAL OF CHROMATOGRAPHY A,1090(1-2),68-75.
MLA	Yin, JF,et al."Rapid and efficient chiral separation of nateglinide and its L-enantiomer on monolithic molecularly imprinted polymers".JOURNAL OF CHROMATOGRAPHY A 1090.1-2(2005):68-75.